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RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF (show VWF Proteins), as exemplified by increased exposure of antibody-binding sites.
Here two crystal structures are presented: the structure of human PIK42A (show PI4K2A Proteins) and the structure of PIK42B containing a nucleoside analogue.
Results provide evidence that type II PtdIns 4-kinase b was indeed recruited to CD4 (show CD4 Proteins)- p56lck (show LCK Proteins) complex upon CD4 receptor cross linking, suggests a mechanism for its association and a role for it in CD4 (show CD4 Proteins)-mediated intracellular calcium release.
type II PtdIns 4-kinase beta (show PI4KB Proteins) is a key component in early T cell activation signaling cascades
There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded.
Type II PtdIns 4-kinase beta (show PI4KB Proteins) interacts with TCR-CD3 zeta (show CD247 Proteins) chain. The C-terminal ITAM is critical for enzyme docking on the zeta chain. The association is tyrosyl phosphorylation dependent. Mutation of Y-151 & Y-142 disrupts interaction of the 2 proteins.
LB-PI4K2B-1S-specific CD4 (show CD4 Proteins)(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8 (show CD8A Proteins)(+) T cell immunity as helper cells.
PI 4-kinase functions to negatively regulate GLUT4 (show SLC2A4 Proteins) translocation through its interaction with NCS-1 (show NCS1 Proteins).
PI4-kinase type 2beta (PI4K2beta) is identified as a regulator of the trans-Golgi network (TGN (show TG Proteins))/endosomal sorting and Wnt (show WNT2 Proteins) signaling. PI4K2beta and AP-1 (show JUN Proteins) interact directly and are required for efficient sorting between endosomes and the TGN (show TG Proteins).
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002
phosphatidylinositol 4-kinase type 2-beta
, phosphatidylinositol 4-kinase type II-beta
, phosphatidylinositol 4-kinase type 2 beta
, phosphatidylinositol 4-kinase type 2-beta-like
, phosphatidylinositol 4-kinase type-II beta
, type II phosphatidylinositol 4-kinase beta
, phosphatidylinositol 4-kinase II beta
, pi4kII beta