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VEGF (show VEGFA Proteins)/PlGF (show PGF Proteins) levels were higher in neonates exposed to pre-eclampsia, and there was a significant negative correlation between birth weight and VEGF (show VEGFA Proteins)/PlGF (show PGF Proteins) levels.
There is a significant negative correlation between the concentration of sFLt-1 and PlGF (show PGF Proteins) in normal pregnancy.
Data showed that sFlt-1/PlGF (show PGF Proteins) ratio increases with volume overload and persistent hypoxia after surgery with CHD (show CHDH Proteins).
Glioma cell-released PlGF (show PGF Proteins) can induce Bregs to suppress CD8 (show CD8A Proteins)(+) T cell activities.
In chronic kidney patients not yet on dialysis, higher serum level of PIGF are associated with increased mortality, but not cardiovascular events.
A highly conserved motif in PIGF is not involved in binding to PIGO (show PIGO Proteins) or PIGG (show PIGG Proteins), but critical for its function.
In high-risk patients the sFlt1 (show FLT1 Proteins)/PlGF (show PGF Proteins) ratio can be used for an individual risk assessment with regard to PE, HELLP syndrome or IUGR. Serial measurements permit a risk-adapted prenatal care of these patients
PIGF gene is upregulated in patients diagnosed with retinal reactive astrocytic tumors.
Soluble flt1 (show FLT1 Proteins) is increased in preeclampsia and is associated with decreased levels of bioactive PiGF.
IL-17A (show IL17A Proteins), IL-17B (show IL17B Proteins), IL-17F (show IL17F Proteins) and IL-23 (show IL23A Proteins) in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF (show VEGFA Proteins), PIGF, as well as number of endothelial cells, was investigated.
PGF (show PTGFR Proteins) deficiency is associated with impaired cerebral vascular development in mice.
PlGF (show PGF Proteins) inhibition attenuates PERK (show EIF2AK3 Proteins) activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Proteins) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
Placenta growth factor (show PGF Proteins) augments airway hyperresponsiveness via leukotrienes and IL-13 (show IL13 Proteins).
Data indicate that placental growth factor (PlGF (show PGF Proteins)) is needed in the spleen to allow the activation of T cells and blood pressure raising.
Placental growth factor (show PGF Proteins) promotes differentiation of bone marrow-derived macrophages and enhanced vascular endothelial cell proliferation.
PLGF (show PGF Proteins) in LC cells induced macrophage polarization in vivo, and significantly promoted the growth of LC.
PLGF (show PGF Proteins) is upregulated in vascular cells in response to fluid shear stress.
Data suggests that PLGF (show PGF Proteins) may target islet endothelia to release growth factors activating PI3k signalling in beta cells to increase their proliferation. In Pre-Eclampsia, PLGF (show PGF Proteins) reduction impairs these processes resulting in gestational diabetes mellitus.
The neutrophil elastase (show ELANE Proteins)-PlGF (show PGF Proteins)-JNK (show MAPK8 Proteins)/PKCdelta (show PKCd Proteins) pathway contributes to the pathogenesis of lung epithelial cell apoptosis and emphysema.
E2F1 (show E2F1 Proteins) limits cardiac neovascularization and functional recovery after myocardial infarction by suppressing VEGF (show VEGFA Proteins) and PlGF (show PGF Proteins) up-regulation through p53 (show TP53 Proteins)-dependent and -independent mechanisms, respectively.
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described.
, phosphatidylinositol-glycan biosynthesis class F protein
, phosphatidylinositol glycan, class F
, placenta growth factor