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Ptrh2 (show PTRH2 Proteins) levels were up-regulated in dystrophin (show DMD Proteins) deficient mdx (show DMD Proteins) muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx (show DMD Proteins) muscle and Duchenne muscular dystrophy (show DMD Proteins) patients. Similar to the a7 integrin, Ptrh2 (show PTRH2 Proteins) expression was decreased in laminin-a2 null gastrocnemius muscle
Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.
loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan (show SSPN Proteins)-null mice
Integrin alpha 7 integrin beta1 confers a protective effect in dystrophic muscle through the activation of the ILK (show ILK Proteins), AKT (show AKT1 Proteins), p70S6K (show RPS6KB1 Proteins) and BAD signaling to promote muscle cell survival.
Up-regulation of integrin alpha 7 expression mediated by TGF-beta 1 (show TGFB1 Proteins) plays a role in the intraepithelial location of mucosal mast cells in vivo.
the interaction of c-Myc (show MYC Proteins) with the promoter region of Itga7 is an important regulatory element controlling alpha7 integrin expression during muscle development and myotendinous (show TNC Proteins) junction formation
FHL2 (show FHL2 Proteins) and FHL3 (show FHL3 Proteins), respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells
sarcoglycan (show SGCD Proteins) and integrin alpha7beta1 have overlapping roles in mediating cytoskeletal-membrane-extracellular matrix interaction
Increased in vitro binding of integrin alpha7beta1 to laminin after ADP-ribosylation of the 37-kDa fragment of alpha7 requires the presence of Mn2+ and it is not observed in the presence of Mg2 (show MCOLN1 Proteins)+
deltaEF1 has a role in suppressing integrin alpha 7 expression in myoblasts by displacing MYOD (show MYOD1 Proteins) and competing for p300/CBP (show CREBBP Proteins) co-activator
Taken together, these results further support the use of a7 integrin as a potential therapy for Duchenne muscular dystrophy (show DMD Proteins)
Data indicate that S100 calcium binding protein P (S100P (show S100P Proteins)) increased lung cancer cell migration by binding integrin alpha7.
Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma.
ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3 (show TIMP3 Proteins)) in prostate cancer cells.
Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7]
Alpha7beta1D integrin modifies Ca2 (show CA2 Proteins)+ regulatory pathways and offers a means to protect the myocardium from ischemic injury.
This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor.
ILK (show ILK Proteins) interaction with MCM7 (show MCM7 Proteins) and MCM7 (show MCM7 Proteins) phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression.
conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, integrin alpha 7 chain
, alpha 7A integrin