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The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.
Cnot1, Cnot2, and Cnot3 (show CNOT3 Proteins) represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs (show NR2E3 Proteins).
human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4 (show CCR4 Proteins)-NOT complex, thereby affecting cell viability.
This study shows that SMRT/NCoR (show NCOR1 Proteins)-HDAC3 (show HDAC3 Proteins) complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4 (show CCR4 Proteins)-Not complex involves regulation of chromatin modification.
major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box
These findings suggest that CDK11 (show CDK11B Proteins) may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
These data have uncovered a novel role of core components of the Ccr4 (show CCR4 Proteins)-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.
, CCR4-NOT transcription complex subunit 2
, CCR4-NOT transcription complex, subunit 2
, CCR4-NOT transcription complex subunit 2-like
, CCR4-associated factor 2
, negative regulator of transcription 2