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The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
In conclusion, DAB2 and Intelectin-1 (show ITLN1 Proteins) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma
cathepsin B (CTSB (show CTSB Proteins)) inhibition or expression of a CTSB (show CTSB Proteins)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (show TGFB1 Proteins)-treated cells from autophagy to apoptosis
abundances of megalin (show LRP2 Proteins) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries
Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (show TGFB1 Proteins) which contributes to cell migration by targeting DAB2 in cervical carcinoma.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
inhibition of WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.
DAB2 regulated the cell migration associated genes in PC3 (show PCSK1 Proteins) cells, and the differential DAB2 expression between LNCaP and PC3 (show PCSK1 Proteins) cells was partly regulated by histone 4 acetylation.
Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (show CFTR Proteins) by ~18% and ~91%, respectively
These results indicated that miR (show MLXIP Proteins)-93 plays an important role in the initiation and progression of NPC (show NPC1 Proteins) by targeting Dab2 and the miR (show MLXIP Proteins)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (show NPC1 Proteins) in the future.
The combination of Arh (show LDLRAP1 Proteins) and Dab2 is responsible for the majority of adaptor function in LDLR (show LDLR Proteins) endocytosis and LDLR (show LDLR Proteins)-mediated cholesterol homeostasis.
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
Dab2 expression is induced by hormones
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 Proteins) in mice.
Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) are involved in albumin (show ALB Proteins) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 Proteins) induces albumin (show ALB Proteins) endocytosis in proximal tubule epithelial cells.
Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2, and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein