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High PHB expression is associated with breast cancer.
Data shows that PHB protein was overexpressed in gallbladder cancer tissues and significantly associated with histological grade, tumor stage and perineural invasion.
The present review focus is on recent developments in prohibitin (PHB) research in relation to ovarian granulosa cells physiological functions. [review]
We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF (show RAF1 ELISA Kits) signalling pathway), PHB can act as a signalling scaffold protein (show HOMER1 ELISA Kits) to assist in KDELR-dependent Src (show SRC ELISA Kits) activation
a majority of patients with IgG4-related disease have antibodies against prohibitin.
PHB phosphorylated at threonine 258 and MIG-7 (show TOX4 ELISA Kits) may play complementary roles in the initiation and sustainment of the effects of growth factors and COX-2 (show COX2 ELISA Kits)/PGE2 on cancer invasion/metastasis.
miR (show MLXIP ELISA Kits)-27a was shown to be a significant tumor suppressor by targeting and decreasing PHB protein expression in glioma U251 cells. miR (show MLXIP ELISA Kits)-27a targeting of PHB may be a novel potential therapeutic strategy for glioma
Less expression of prohibitin is associated with increased paired box 2 (show PAX2 ELISA Kits) in renal interstitial fibrosis
A protective role of PHB that is dependent on pS727-Stat3 (show STAT3 ELISA Kits) to prevent mitochondrial dysfunction in intestinal epithelial cells.
Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis.
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.
This study identifies a novel signaling pathway composed of miR (show MLXIP ELISA Kits)-361 and PHB1 that regulates mitochondrial fission program and apoptosis.
Both c-Myc (show MYC ELISA Kits) and PHB1 directly interact with Nrf2 (show NFE2L2 ELISA Kits) but c-Myc (show MYC ELISA Kits) lowers Nrf2 (show NFE2L2 ELISA Kits) binding to antioxidant response elemens while PHB1 enhances it.
A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI (show FCGR1A ELISA Kits) and Syk (show SYK ELISA Kits).
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (show HMOX1 ELISA Kits) and NQO-1 (show NQO1 ELISA Kits) via a mechanism independent of Nfe2 (show NFE2 ELISA Kits)
Phb1/2 and the CD86 (show CD86 ELISA Kits) cytoplasmic domain cooperate to mediate CD86 (show CD86 ELISA Kits) signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.
Findings suggest that PHB protects against colitis-associated cancer by modulating p53 (show TP53 ELISA Kits)- and STAT3 (show STAT3 ELISA Kits)-mediated apoptosis.
Phb1 deficiency is a potential driver of chronic liver diseases by inducing hepatocyte damage and inflammation.
Identified PHB as an important protein in adipocyte differentiation. Furthermore, the overexpression of PHB in 3T3-L1 fibroblasts was sufficient to induce adipogenesis.
Data show that protein-tyrosine phosphatase (show ACP1 ELISA Kits) PRP4A3 (prl3 (show PTP4A3 ELISA Kits)) and van gogh like1 (vangl1 (show Vangl1 ELISA Kits)) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.
Xphb1 represses E2F1 (show E2F1 ELISA Kits) activity.
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
, prohibitin protein Wph
, B-cell receptor-associated protein 32