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decrease of PCMT1 (show PCMT1 ELISA Kits) significantly increased the proportion of D-Asp (show ASIP ELISA Kits) residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system
Endoplasmic reticulum resident chaperone GRP78 (show HSPA5 ELISA Kits), mitochondrial protein (show COX6B2 ELISA Kits) Prohibitin and heterogeneous nuclear ribonucleoprotein (show PCBP2 ELISA Kits) hnRNPC (show HNRNPC ELISA Kits) (C1/C2) have been shown to interact with viral RNA. Hence it is proposed that these are the principle candidates governing endoplasmic reticulum stress-induced apoptosis in JEV infection.
PHB1 down regulation suppresses liver cancer and bile duct cancer tumorigenesis.
PHB has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA (show HIRA ELISA Kits) in chromatin organization to link epigenetic organization to a metabolic circuit.
results demonstrate that the H19 (show NCKAP1 ELISA Kits)-Igf2 axis is negatively regulated by CTCF (show CTCF ELISA Kits)-PHB1 cooperation and that H19 (show NCKAP1 ELISA Kits) is involved in modulating the growth-suppressive effect of PHB1 in the liver.
PHB promotes AR activation in ER-positive breast cancer.
High PHB expression is associated with breast cancer.
Data shows that PHB protein was overexpressed in gallbladder cancer tissues and significantly associated with histological grade, tumor stage and perineural invasion.
The present review focus is on recent developments in prohibitin (PHB) research in relation to ovarian granulosa cells physiological functions. [review]
We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF (show RAF1 ELISA Kits) signalling pathway), PHB can act as a signalling scaffold protein (show HOMER1 ELISA Kits) to assist in KDELR-dependent Src (show SRC ELISA Kits) activation
obesity-associated hyperinsulinemia promotes tumor development by facilitating dormant mutant to manifest and reveals a sex-dimorphic role of PHB in adipose-immune interaction or immunometabolism.
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.
This study identifies a novel signaling pathway composed of miR (show MLXIP ELISA Kits)-361 and PHB1 that regulates mitochondrial fission program and apoptosis.
Both c-Myc (show MYC ELISA Kits) and PHB1 directly interact with Nrf2 (show NFE2L2 ELISA Kits) but c-Myc (show MYC ELISA Kits) lowers Nrf2 (show NFE2L2 ELISA Kits) binding to antioxidant response elemens while PHB1 enhances it.
A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI (show FCGR1A ELISA Kits) and Syk (show SYK ELISA Kits).
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (show HMOX1 ELISA Kits) and NQO-1 (show NQO1 ELISA Kits) via a mechanism independent of Nfe2 (show NFE2 ELISA Kits)
Phb1/2 and the CD86 (show CD86 ELISA Kits) cytoplasmic domain cooperate to mediate CD86 (show CD86 ELISA Kits) signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.
Findings suggest that PHB protects against colitis-associated cancer by modulating p53 (show TP53 ELISA Kits)- and STAT3 (show STAT3 ELISA Kits)-mediated apoptosis.
Data show that protein-tyrosine phosphatase (show ACP1 ELISA Kits) PRP4A3 (prl3 (show PTP4A3 ELISA Kits)) and van gogh like1 (vangl1 (show Vangl1 ELISA Kits)) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.
Xphb1 represses E2F1 (show E2F1 ELISA Kits) activity.
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
, prohibitin protein Wph
, B-cell receptor-associated protein 32