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Browse our SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (SMARCA4)

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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (SMARCA4)
On www.antibodies-online.com are 6 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) Proteins from 3 different suppliers available. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Antibodies (99) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Kits (1) and many more products for this protein. A total of 108 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 products are currently listed.
Synonyms:
b2b692Clo, BAF190, BAF190A, brg-1, Brg1, HP1-BP72, hSNF2b, MRD16, RTPS2, SMARCA4, SNF2, SNF2beta, SNF2L4, SNF2LB, SW1/SNF, SWI2
list all proteins Gene Name GeneID UniProt
SMARCA4 6597 P51532
Rat SMARCA4 SMARCA4 171379  
SMARCA4 20586 Q3TKT4

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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Proteins (SMARCA4) by Origin

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More Proteins for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. BRG1 participates in gene repression by interacting with H1.2 (show HIST1H1C Proteins), facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.

  2. Cdx (show CDX1 Proteins) members interact with the SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins) complex and make direct contact with Brg1, a catalytic member of SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins). Both Cdx2 (show CDX2 Proteins) and Brg1 co-occupy a number of Cdx (show CDX1 Proteins) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (show CDX2 Proteins) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.

  3. BRG1/BRM (show SMARCA2 Proteins) and c-MYC (show MYC Proteins) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Proteins) in cancer.

  4. Small-cell carcinoma of the ovary of hypercalcemic type is characterized by deleterious germline or somatic mutations in SMARCA4.

  5. SMARCA4 and SMARCA2 (show SMARCA2 Proteins) deficiency is observed in 5.1% and 4.8% of non-small cell lung cancer

  6. BRG1 is involved in the progression and metastasis of breast cancer and can serve as a novel biomarker predictive of distant metastasis and patient outcomes.

  7. Results provide evidence that BRG1 and SMARCAL1 (show SMARCAL1 Proteins) regulate each other. BRG1 binds to the SMARCAL1 (show SMARCAL1 Proteins) promoter, while SMARCAL1 (show SMARCAL1 Proteins) binds to the brg1 promoter. During DNA damage, the occupancy of SMARCAL1 (show SMARCAL1 Proteins) on the brg1 promoter increases coinciding with an increase in BRG1 occupancy on the SMARCAL1 (show SMARCAL1 Proteins) promoter, leading to increased brg1 and SMARCAL1 (show SMARCAL1 Proteins) transcripts respectively.

  8. The CRISPR/Cas9 system may control a pro-oncogenic splicing process through the exclusion of EDA (show EDA Proteins) exon from the FN gene, leading to inhibition of motility, invasion and proliferation of cancer cells.

  9. Knock down of BRG1 in resistant cells restored sensitivity to retinoic acid-mediated differentiation, from early gene expression to terminal functional capacity.

  10. Data indicate that SMARCA4 protein inactivation is the main cause of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  2. Cdx (show CDX1 Proteins) members interact with the SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins) complex and make direct contact with Brg1, a catalytic member of SWI (show SMARCA1 Proteins)-SNF (show SNRPA Proteins). Both Cdx2 (show CDX2 Proteins) and Brg1 co-occupy a number of Cdx (show CDX1 Proteins) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (show CDX2 Proteins) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.

  3. BRG1/BRM (show SMARCA2 Proteins) and c-MYC (show MYC Proteins) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Proteins) in cancer.

  4. Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 (show TP53 Proteins) program, to constrain gene expression and facilitate rapid embryonic growth.

  5. Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation

  6. SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin remodeler subunits Brg1 and Brm (show SMARCA2 Proteins) are expressed differentially during drug-induced liver injury and regeneration in a mouse model.

  7. these findings described a role for BRG1 and BRM (show SMARCA2 Proteins) in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte

  8. show that epigenetic chromatin remodeling (via a Brg1 and p53 (show TP53 Proteins)/p21-dependent process) determines the aNSCs and progenitor maintenance and responsiveness of neurogenesis.

  9. The stress-induced Brg1-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  10. MITF (show MITF Proteins) interacts with BRG1 to promote GATA4 (show GATA4 Proteins) expression in cardiac hypertrophy.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4)

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4)
  • b2b692Clo protein
  • BAF190 protein
  • BAF190A protein
  • brg-1 protein
  • Brg1 protein
  • HP1-BP72 protein
  • hSNF2b protein
  • MRD16 protein
  • RTPS2 protein
  • SMARCA4 protein
  • SNF2 protein
  • SNF2beta protein
  • SNF2L4 protein
  • SNF2LB protein
  • SW1/SNF protein
  • SWI2 protein

Protein level used designations for SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 , transcription activator BRG1-like , ATP-dependent helicase SMARCA4 , BRG1-associated factor 190A , BRM/SWI2-related gene 1 , SNF2-beta , SNF2-like 4 , brahma protein-like 1 , global transcription activator homologous sequence , homeotic gene regulator , mitotic growth and transcription activator , nuclear protein GRB1 , protein BRG-1 , protein brahma homolog 1 , sucrose nonfermenting-like 4 , transcription activator BRG1 , BAF190A , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 , SWI/SNF related transcriptional activator , WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

GENE ID SPECIES
455720 Pan troglodytes
476710 Canis lupus familiaris
100415454 Callithrix jacchus
100446301 Pongo abelii
100464834 Ailuropoda melanoleuca
6597 Homo sapiens
171379 Rattus norvegicus
20586 Mus musculus
414274 Bos taurus
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