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Human Monoclonal IL7 Primary Antibody for ICFC - ABIN2665850
Melchers, Haasner, Streb, Rolink: B-lymphocyte lineage-committed, IL-7 and stroma cell-reactive progenitors and precursors, and their differentiation to B cells. in Advances in experimental medicine and biology 1993
Show all 3 references for ABIN2665850
Human Monoclonal IL7 Primary Antibody for ICFC - ABIN2661242
Park, Morrissey, Davison, Grabstein: The role of IL-7 and its receptor in B-cell ontogeny. in Advances in experimental medicine and biology 1993
Show all 3 references for ABIN2661242
increased IL-7 protein production in situ (lung tissue) from non-human primates who received rBCG vaccination, which was associated with increased survival.
Increase in serum IL-7 is associated with adenoma.
provides negative feedback on its own signaling in T cells via endocytosis and degradation of its receptor, CD127 (show IL7R Antibodies)
Observed highly significant reductions in the concentration of circulating interleukin (IL)-16 (show IL16 Antibodies), IL-7, and Vascular Endothelial Growth Factor A (VEGF-A (show VEGFA Antibodies)) in encephalomyelitis/chronic fatigue syndrome patients.
The observations suggest that IL-7 may play a role in the pathogenesis of Graves' disease and may be associated with its clinical activity.
IL-7 and SCF (show KITLG Antibodies) are elevated for a prolonged period after double umbilical cord blood transplantation and persistently high levels of these cytokines may correlate with worse clinical outcomes.
Common gamma-chain (show IL2RG Antibodies) cytokines IL-2 (show IL2 Antibodies), IL-7, and IL-15 (show IL15 Antibodies) prevent differentiation of naive T cells in vitro and limit activation of primed T cells in the absence of antigenic stimulus, which can contribute to the formation of cytokine imbalance.
IL7 was expressed primarily in the infundibulum and s (show CD8A Antibodies)uprabulb (show CD4 Antibodies)of the hair follicle. IL7 expression was increased in cutaneous T-cell lymphoma.
this study identified that IL-7, as well as the Akt (show AKT1 Antibodies)/ mTOR (show FRAP1 Antibodies) signaling pathway, effectively modulates human Double-Negative T Cell- mediated suppression of allogeneic T cell responses.
IL-7/IL-17 (show IL17A Antibodies) axis mediates chronic pelvic pain in experimental autoimmune prostatitis and in patients.
In view of the important role IL-7 plays in lymphocyte proliferation, homeostasis and survival, down regulation of CD127 (show IL7R Antibodies) by Tat (show TAT Antibodies) likely plays a central role in immune dysregulation and CD4 (show CD4 Antibodies) T-cell decline
functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
continuous IL7 signaling was not required for tumor regression, although LIP of naive CD8 (show CD8A Antibodies)+ T cells is usually regulated by IL7
IL7 represses the follicular helper T cell gene program.
This study uncovers the metabolic mechanisms by which IL-7 tailors the metabolism of memory T cells to promote their longevity and fast response to rechallenge.
IL-7 reduced IRAK-M (show IRAK3 Antibodies) expression and attenuated immune tolerance induced by either LPS (show TLR4 Antibodies) or CpGA
Poly I:C induces IL-7 production, early inflammatory responses, and characteristic pathologies of SS-like dacryoadenitis in non-autoimmune-prone C57BL/6 mice.
Data show that interleukin 7 (IL-7) signaling is a prerequisite for optimal CD4 (show CD4 Antibodies)(+) T cell activation.
reduced surface expression of IL-7R and concomitant limited responsiveness to IL-7 signals as a common mechanism resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double-negative to double-positive transition
Hair follicle expression of IL-7 was required for CD8 (show CD8A Antibodies)+ and CD4 (show CD4 Antibodies)+ skin-resident memory T (TRM) cells to exert tropism for the epidermis. In a cutaneous T cell lymphoma model, CD4 (show CD4 Antibodies)+ TRM lymphoma cell localization depended on hair follicle-derived IL-7.
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.