Browse our anti-STAT1 (STAT1) Antibodies

Full name:
anti-Signal Transducer and Activator of Transcription 1, 91kDa Antibodies (STAT1)
On www.antibodies-online.com are 635 Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies from 39 different suppliers available. Additionally we are shipping STAT1 Kits (46) and STAT1 Proteins (21) and many more products for this protein. A total of 747 STAT1 products are currently listed.
Synonyms:
2010005J02Rik, AA408197, CANDF7, DD6G4-4, dZ182H3.3, H2RSP, IMUP, IMUP-1, IMUP-2, ISGF-3, si:by51f19.1, si:by134g18.2, si:dz73o4.2, si:dz182h3.3, si:dz199m19.1, STAT, STAT1, STAT4, STAT91, XStat1
list all antibodies Gene Name GeneID UniProt
STAT1 72275  
STAT1 25124  
STAT1 6772 P42224

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Top referenced anti-STAT1 Antibodies

  1. Human Polyclonal STAT1 Primary Antibody for EIA, IHC (p) - ABIN358231 : Garcin, Marq, Iseni, Martin, Kolakofsky: A short peptide at the amino terminus of the Sendai virus C protein acts as an independent element that induces STAT1 instability. in Journal of virology 2004 (PubMed)
    Show all 5 references for 358231

  2. Human Polyclonal STAT1 Primary Antibody for IF (p), IHC (p) - ABIN674889 : Wang, Wang, Song, Chu, Qu: Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015 (PubMed)
    Show all 3 references for 674889

  3. Human Monoclonal STAT1 Primary Antibody for IHC (p), IP - ABIN269146 : Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation. in International journal of molecular medicine 2003 (PubMed)
    Show all 2 references for 269146

  4. Cow (Bovine) Polyclonal STAT1 Primary Antibody for IHC, WB - ABIN2780843 : Battle, Lynch, Frank: Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. in Cancer research 2006 (PubMed)
    Show all 2 references for 2780843

  5. Human Polyclonal STAT1 Primary Antibody for IF, IHC - ABIN1533008 : Durbin, Hackenmiller, Simon, Levy: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. in Cell 1996 (PubMed)
    Show all 2 references for 1533008

  6. Human Polyclonal STAT1 Primary Antibody for ELISA, WB - ABIN1533729 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

More Antibodies against STAT1 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. In cultured macrophages, LPS (show TLR4 Antibodies)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CPT1B Antibodies) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (show NFKBIZ Antibodies) activities.

  2. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (show MAPK14 Antibodies), AAT (show SERPINA1A Antibodies), signal transducer and activator of transcription 1 (STAT1) and activating transcription factor2 (ATF2 (show ATF2 Antibodies))

  3. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2 (show CHD4 Antibodies)/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription.

  4. Microbiome depletion as a result of broad-spectrum antibiotic treatment disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor maintenance and granulocyte maturation.

  5. We revealed that in mouse mesenchymal stem cells IFN-gamma-induced (show SAMHD1 Antibodies) immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3 (show STAT3 Antibodies), which is significantly enhanced by an extracellular signal-regulated kinase 1/2 (show MAPK3 Antibodies)-dependent mTOR (show FRAP1 Antibodies) inhibition, thereby promoting pSTAT1 nuclear translocation.

  6. these results define a differential regulation of TLR-mediated activation and differentiation of MZ B cells by STAT1 and reveal a STAT1-dependent, but IFN-independent, antibody response during infection and inflammation.

  7. B cell-intrinsic IFN-gamma (show IFNG Antibodies) receptor (IFN-gammaR (show IFNGR1 Antibodies)) and STAT1 signaling are required for Spontaneously developed germinal centers and follicular T helper cell (Tfh cell) development.

  8. Inhibitor-sensitive tyrosine kinase (show TYRO3 Antibodies) controls the population heterogeneity of basal STAT1 activity in Ube1l (show UBA7 Antibodies) deficient fibroblasts.

  9. The studies presented here reveal that the ability of IFN-gamma (show IFNG Antibodies) to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS).

  10. We found that STAT-1(-/-) MRL lpr (show FAS Antibodies) mice, but not IRF-9 (show IRF9 Antibodies)(-/-) or IFNAR-2 (show IFNAR2 Antibodies)(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils. Despite pronounced interstitial kidney disease and abnormal kidney function, STAT-1(-/-) mice had decreased proteinuria, glomerulonephritis, and autoantibody production.

Human Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. MFSD2B, CCL20 (show CCL20 Antibodies) and STAT1, or STARD7 (show STARD7 Antibodies) and ZNF512 (show ZNF512 Antibodies) genes may be risk or protect factors in prognosis of ADC (show ADC Antibodies); HTR2B (show HTR2B Antibodies), DPP4 (show DPP4 Antibodies), and TGFBRAP1 (show TGFBRAP1 Antibodies) genes may be risk factors in prognosis of SQC (show QPCT Antibodies).

  2. In cultured macrophages, LPS (show IRF6 Antibodies)-induced expression of monocyte chemoattractant protein (MCP)-1 (show CCL2 Antibodies) was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta (show NFKBIZ Antibodies) activities.

  3. Functional analysis of NK cells shows a significant impairment of cytolytic and degranulation activities in chronic mucocutaneous candidiasis patients with STAT1 GOF mutations

  4. Mechanistic investigations reveal that AJUBA (show AJUBA Antibodies) specifically binds the FERM domain of JAK1 (show JAK1 Antibodies) to dissociate JAK1 (show JAK1 Antibodies) from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (show AJUBA Antibodies) in CRC (show CALR Antibodies) specimens is negatively correlated with the levels of IFIT2 (show IFIT2 Antibodies) and pSTAT1

  5. Low STAT1 expression is associated with Pancreatic cancer.

  6. STAT1 and IRF1 (show IRF1 Antibodies) collaborate to induce interferon-gamma (show IFNG Antibodies) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 and IRF1 (show IRF1 Antibodies) at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.

  7. IFITM1 (show IFITM1 Antibodies) suppression blocks proliferation and invasion of aromatase (show CYP19A1 Antibodies) inhibitor-resistant breast cancer in vivo by JAK (show JAK3 Antibodies)/STAT1-mediated induction of p21 (show CDKN1A Antibodies).

  8. This study reports a new role for SETD2 (show SETD2 Antibodies) in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15 (show ISG15 Antibodies)) to activate gene transcription. Thus, SETD2 (show SETD2 Antibodies) enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.

  9. STAT1 gain-of-function mutations underlie Autosomal dominant chronic mucocutaneous candidiasis, as well as an unexpectedly wide range of other clinical features, including not only a variety of infectious and autoimmune diseases, but also cerebral aneurysms and carcinomas that confer a poor prognosis.

  10. Six different heterozygous mutations in STAT1 were detected in the seven patients (Patients 3 and 4 shared identical mutations). Three of these mutations were recurrent variants (p.R274Q, p.K388E and p.P329L), whereas the other three (p.N357D, p.M202T, and p.T437I), involving both the coiled coil domain (CCD (show RUNX2 Antibodies)) and DNA binding domain (DBD), have not been reported previously.

Pig (Porcine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (show IFNA Antibodies) response by inducing STAT1 degradation.

  2. this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets

  3. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (show JAK3 Antibodies)-STAT1) signaling pathway.

  4. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (show STAT2 Antibodies) nuclear translocation.

  5. Nsp1beta inhibits interferon-activated (show MNDA Antibodies) STAT1/STAT2 (show STAT2 Antibodies) signal transduction by inducing karyopherin-alpha1 degradation.

  6. STAT1 is involved in mediating the action of ghrelin (show GHRL Antibodies) on ovarian cell functions.

  7. the majority of the STAT1/STAT2 (show STAT2 Antibodies)/IRF9 (show IRF9 Antibodies) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

  8. Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.

  9. Nitric oxide-dependent increase in caspase-8 (show CASP8 Antibodies) mRNA levels is associated with phosphorylation of STAT-1 at Ser (show SIGLEC1 Antibodies)-727 and STAT1 binding to the caspase-8 (show CASP8 Antibodies) promoter in cultured lung endothelial cells.

  10. Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.

Cow (Bovine) Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) interaction partners

  1. Report interferon-tau dependent STAT1 regulation of SOCS (show CISH Antibodies) genes in bovine endometrium during estrus cycle and embryo implantation.

  2. the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate

  3. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes

  4. Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (show CSN2 Antibodies) synthesis and fat metabolism.

  5. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (show STAT2 Antibodies).

STAT1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT1

  • signal transducer and activator of transcription 1, 91kDa (STAT1) antibody
  • RIKEN cDNA 2200002D01 gene (2200002D01Rik) antibody
  • signal transducer and activator of transcription 1 (Stat1) antibody
  • signal transducer and activator of transcription 1, 91kDa (stat1) antibody
  • signal transducer and activator of transcription 4 (stat4) antibody
  • 2010005J02Rik antibody
  • AA408197 antibody
  • CANDF7 antibody
  • DD6G4-4 antibody
  • dZ182H3.3 antibody
  • H2RSP antibody
  • IMUP antibody
  • IMUP-1 antibody
  • IMUP-2 antibody
  • ISGF-3 antibody
  • si:by51f19.1 antibody
  • si:by134g18.2 antibody
  • si:dz73o4.2 antibody
  • si:dz182h3.3 antibody
  • si:dz199m19.1 antibody
  • STAT antibody
  • STAT1 antibody
  • STAT4 antibody
  • STAT91 antibody
  • XStat1 antibody

Protein level used designations for STAT1

signal transducer and activator of transcription 1-alpha/beta , HAI-2 related small protein , signal transducer and activator of transcription-1 , transcription factor ISGF-3 components p91/p84 , signal transducer and activator of transcription 4 , signal transducer and activator of transcription 1 , transcription factor ISGF-3 , activator of transcription , signal transduction

GENE ID SPECIES
100307049 Ovis aries
72275 Mus musculus
20846 Mus musculus
25124 Rattus norvegicus
6772 Homo sapiens
424044 Gallus gallus
488449 Canis lupus familiaris
396655 Sus scrofa
510814 Bos taurus
398324 Xenopus laevis
100343893 Oryctolagus cuniculus
368519 Danio rerio
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