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STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (N-Term) Primary Antibody

STAT1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio) IHC, WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN2780843
$229.00
Plus shipping costs $45.00
100 μL
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  • Target
    STAT1
    Binding Specificity
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio)
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This STAT1 antibody is un-conjugated
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    Sequence
    MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV
    Predicted Reactivity
    Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 86%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against STAT1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human STAT1
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 750 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Deng, Chen, Li, Yuan, Li, Ke, Wang, Wu, Luo: "Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 10555-64, 2015 (PubMed).

  • Target
    STAT1
    Alternative Name
    STAT1 (STAT1 Antibody Abstract)
    Synonyms
    CANDF7, ISGF-3, STAT91, 2010005J02Rik, AA408197, XStat1, STAT4, DD6G4-4, STAT, STAT1, dZ182H3.3, si:by134g18.2, si:by51f19.1, si:dz182h3.3, si:dz199m19.1, si:dz73o4.2, stat1, signal transducer and activator of transcription 1, signal transducer and activator of transcription 1 L homeolog, signal transducer and activator of transcription 1, 91kDa, signal transducer and activator of transcription 4, signal transducer and activator of transcription 1a, STAT1, Stat1, stat1.L, stat4, stat1a
    Background
    STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
    Alias Symbols: DKFZp686B04100, ISGF-3, STAT91, CANDF7
    Protein Interaction Partner: HUWE1, ISG15, PIAS1, UBC, STAT1, EIF1AD, OTUD4, LMO2, GNB2, DTX3L, EGFR, NAA15, SNX6, CAND1, VPS29, GSPT2, JMJD6, RTF1, HSPA4L, ATG7, YAP1, PAWR, KARS, IDE, CTTN, VPS26A, HIRIP3, NAA10, TSNAX, TBCD, SNX2, SNX1, SHMT2, SHMT1, SARS, ATP6V1C1, APEH, USP13, E
    Protein Size: 750
    Molecular Weight
    87 kDa
    Gene ID
    6772
    NCBI Accession
    NM_007315, NP_009330
    UniProt
    P42224
    Pathways
    JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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