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Human Polyclonal CCP110 Primary Antibody for ELISA, WB - ABIN4288914
DAngiolella, Donato, Vijayakumar, Saraf, Florens, Washburn, Dynlacht, Pagano: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. in Nature 2010
CP110 is required for anchoring of basal bodies to the membrane during cilia formation. CP110 loss resulted in an abnormal distribution of core components of subdistal appendages and of recycling endosomes, which may be associated with premature extension of axonemal microtubules. CP110 has unique context-dependent functions, acting as both a suppressor and a promoter of ciliogenesis.
miR-129-3p, a microRNA conserved in vertebrates, controls cilia biogenesis in cultured cells by concomitantly downregulating CP110 and repressing branched F-actin formation.
We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR (show MLXIP Antibodies)-129 overexpression rendered the cells sensitive to docetaxel.
Data show thata combining cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) antagonism and ubiquitin thioesterase 33 (USP33 (show USP33 Antibodies)) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations.
Centrin2 regulates primary ciliogenesis through controlling CP110 levels.
Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1 (show FOXJ1 Antibodies), TAp73 (show TP73 Antibodies) were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length
using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33 (show USP33 Antibodies), a deubiquitinating enzyme that is able to regulate CP110 levels
Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients
Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly.
Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
centriolar coiled-coil protein of 110 kDa
, centrosomal protein CP110
, centrosomal protein of 110 kDa