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Dominant alleles of RAD51 (show RAD51 Proteins), TP53 (show TP53 Proteins) and XRCC1 (show XRCC1 Proteins) combined genotypes indicated a strong protective role against hereditary breast cancer.
Intramolecular binding of the rad9 (show RAD9A Proteins) C-terminus in the checkpoint clamp (show PDZK1 Proteins) Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 is closely linked with its DNA binding.
Data show models for the ternary PCNA (show PCNA Proteins)/FEN1 (show FEN1 Proteins)/DNA and Rad9 (show RAD9A Proteins)-Rad1-Hus1 (show HUS1 Proteins) (9-1-1 complex)/FEN1 (show FEN1 Proteins)/DNA assemblies.
The RAD1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.
CK2 (show CSNK2A1 Proteins) plays a crucial role in the ATR (show ANTXR1 Proteins)-dependent checkpoint pathway through its ability to phosphorylate Ser (show SIGLEC1 Proteins)-341 and Ser (show SIGLEC1 Proteins)-387 of the Rad9 (show RAD9A Proteins) subunit of the Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 complex
Rad9 (show RAD9A Proteins)-Rad1-Hus1 (show HUS1 Proteins) complex enhances in vitro activity of 8-oxoguanine DNA glycosylase (show OGG1 Proteins).
Rad9 (show RAD9A Proteins), Hus1 (show HUS1 Proteins), and Rad1 heterotrimeric complex chromatin binding is a proximal event in the checkpoint signaling cascade
RAD1 is a potential intrinsic chaperone in the stabilization of HUS1 (show HUS1 Proteins) for the heterotrimeric (RAD9 (show RAD9A Proteins)-RAD1-HUS1 (show HUS1 Proteins)) checkpoint complex formation.
The human Rad9 (show RAD9A Proteins)/Rad1/Hus1 (show HUS1 Proteins) complex interacts with and stimulates DNA polymerase beta (show POLB Proteins) activity.
complex with rad9 (show RAD9A Proteins) and hus1 (show HUS1 Proteins) is a damage-specific activator of flap endonuclease 1 (show FEN1 Proteins)
HUS1 (show HUS1 Proteins) acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 (show TOPBP1 Proteins) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 (show RAD9A Proteins) or HUS1 (show HUS1 Proteins).
The rad1 protein is required for repairing DNA lesions induced by UV-light, HU and gamma rays, and for mediating G(2)/M and S/M checkpoint controls.
data indicate that Rad1(K185) is not a functional counterpart of PCNA (show PCNA Proteins)(K164).
data suggest that Mrad1 is important for preventing tumor development.
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described.
cell cycle checkpoint protein RAD1
, RAD1 homolog (S. pombe)
, RAD1 homolog
, Cell cycle checkpoint protein RAD1
, cell cycle checkpoint protein rad1
, DNA repair exonuclease REC1
, DNA repair exonuclease rad1 homolog
, cell cycle checkpoint protein Hrad1
, checkpoint control protein HRAD1
, exonuclease homolog RAD1
, rad1-like DNA damage checkpoint protein