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Expression levels of TGF-beta1 (show TGFB1 ELISA Kits) and BMP-2 (show BMP2 ELISA Kits) appeared to be delayed in nonunion patients which could play an important role in developing an early marker of fracture union condition and facilitate improved patient's management.
All members of the tolloid (show BMP1 ELISA Kits) family bind the N terminus of latent TGFb (show TGFB1 ELISA Kits)-binding protein-1, providing support for their role in TGFb (show TGFB1 ELISA Kits) signalling.
Eosinophils enhance Wnt-5a (show WNT5A ELISA Kits), TGF-beta1 (show TGFB1 ELISA Kits), fibronectin (show FN1 ELISA Kits), and collagen gene expression in airway smooth muscle cells and promote proliferation of these cells in asthma.
LTBP-1 and LTBP-2 (show LTBP2 ELISA Kits) are involved in the keratinization of oral epithelium.
LTBP-1 may be a promising biomarker for distinguishing early stage hepatocellular carcinoma from the chronic hepatitis B or liver cirrhosis patients.
Significantly higher frequency of TT genotype of transforming growth factor-Beta 1 (show TGFB1 ELISA Kits) in asthma patients was found compared to controls.
The aim of this study is to evaluate whether specific inhibition of c-Abl (show ABL1 ELISA Kits) by siRNA can influence the transforming growth factor-beta1 (TGF-beta1 (show TGFB1 ELISA Kits))-induced fibrotic responses.
LTBP-1 showed both an accumulation and a striking co-localization with Notch3 (show NOTCH3 ELISA Kits)-ECD (show SHFM1 ELISA Kits) deposits suggesting specific recruitment into aggregates in brain in CADASIL (show NOTCH3 ELISA Kits).
This review concludes that TGF-beta1 (show TGFB1 ELISA Kits) 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner.
LTBP-1 an extracellular matrix protein and key regulator of TGF-beta (show TGFB1 ELISA Kits) bioavailability is a novel HtrA1 (show HTRA1 ELISA Kits) target.Attenuation of TGF-beta (show TGFB1 ELISA Kits) signaling caused by a lack of HtrA1 (show HTRA1 ELISA Kits)-mediated LTBP-1 processing as mechanism underlying CARASIL (show HTRA1 ELISA Kits) pathogenesis.
LTBP1 has a role in female reproduction
Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions.
Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function.
a detailed computational model for TGF-beta (show TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 ELISA Kits)/5/8 and Smad2 (show SMAD2 ELISA Kits)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 ELISA Kits).
miR (show MLXIP ELISA Kits)-133a mediates TGF-beta (show TGFB1 ELISA Kits)-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis.
Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-beta1 (show TGFB1 ELISA Kits)/GARP (show LRRC32 ELISA Kits) complex on their cell surface rather than by secreted latent TGF-beta1 (show TGFB1 ELISA Kits).
results suggest a role for VEGFA (show VEGFA ELISA Kits)-driven tumour growth by TGF-beta (show TGFB1 ELISA Kits) signalling inhibition via paracrine mechanisms in vivo
Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta (show TGFB1 ELISA Kits) signaling and thus determine the cell-type-specific effects of TGF-beta (show TGFB1 ELISA Kits) signaling.
requirement for TGF-beta (show TGFB1 ELISA Kits) signaling into T cells to achieve peripheral CD8 (show CD8A ELISA Kits) but not CD4 (show CD4 ELISA Kits) T-cell tolerance
Ltbp1L is a major regulator of Tgf-beta (show TGFB1 ELISA Kits) activity during valvulogenesis since its absence results in a perturbed Tgf-beta (show TGFB1 ELISA Kits) pathway that causes all Ltbp1L(-/-) valvular defects.
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (show TGFB1 ELISA Kits) binding proteins affecting TGFbeta (show TGFB1 ELISA Kits) bioavailability in the ovary.
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
latent transforming growth factor beta binding protein 1
, latent TGF-beta binding protein 1
, Latent-transforming growth factor beta-binding protein 1
, latent-transforming growth factor beta-binding protein 1-like
, similar to latent transforming growth factor beta binding protein 2
, latent TGFbeta binding protein
, latent-transforming growth factor beta-binding protein 1
, transforming growth factor beta-1-binding protein 1
, latent TGF beta binding protein
, LanC (bacterial lantibiotic synthetase component C)-like 1
, transforming growth factor beta-1-masking protein large subunit
, transforming growth factor-beta (TGF-beta) masking protein large subunit
, latent transforming growth factor binding protein 1