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anti-Mouse (Murine) OS9 Antibodies:
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Human Polyclonal OS9 Primary Antibody for ICC, IF - ABIN251656
Bernasconi, Pertel, Luban, Molinari: A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. in The Journal of biological chemistry 2008
Show all 7 Pubmed References
Human Polyclonal OS9 Primary Antibody for ICC, IF - ABIN249453
Dougan, Hu, Paquet, Greenblatt, Kim, Lilley, Watson, Ploegh: Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. in Molecular and cellular biology 2011
Show all 4 Pubmed References
Human Polyclonal OS9 Primary Antibody for ICC, IF - ABIN407289
Hofmann, Fischer, Nothnagel, Jacobs, Schmid, Wittig, Franke, Gaede, Schürmann, Petrek, Mrazek, Pabst, Grohé, Grunewald, Ronninger, Eklund, Rosenstiel, Höhne, Zissel, Müller-Quernheim, Schreiber: Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. in The European respiratory journal 2013
OS-9 regulates the secretory transport of TRPV4 (show TRPV4 Antibodies) and appears to protect TRPV4 (show TRPV4 Antibodies) subunits from the precocious ubiquitination and ER-associated degradation.
Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1 (show SLC12A1 Antibodies)) prior to glycosylation/processing.
The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation.
The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor (show CASR Antibodies).
OS-9 up-regulates occludin (show OCLN Antibodies) and claudin-1 (show CLDN7 Antibodies) by activating the MAP kinase (MAPK (show MAPK1 Antibodies)) pathway, and thus protects the epithelial barrier function of Caco-2 monolayer under hypoxia condition.
EDEM2 (show EDEM2 Antibodies) and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog (show SHH Antibodies)
Unique regions mediate the interaction between OS-9 and GRP94 (show HSP90B1 Antibodies).
It delivers mutant neuroserpin (show SERPINI1 Antibodies) to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin (show SERPINI1 Antibodies).
long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha (show HIF1A Antibodies) in pancreatic ductal adenocarcinoma.
Data indicate that the interaction of OS-9 and XTP3-B with CD147(CG) was inhibited by mutations to conserved residues in their lectin domains.
OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization
The OS-9 specifically recognizes Manalpha1,6Manalpha1,6Man residues on the processed C-arm through the continuous double tryptophan (WW) motif.
The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
amplified in osteosarcoma
, osteosarcoma amplified 9, endoplasmic reticulum associated protein
, protein OS-9
, osteosarcoma amplified 9
, amplified in osteosarcoma 9
, endoplasmic reticulum lectin 2
, erlectin 2