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|Antigen||Activating Transcription Factor 2 (ATF2) Antibodies|
|Epitope||AA 93-450 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ATF2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-ATF2 AntibodyTarget Details ATF2 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Cyclic AMP-dependent transcription factor ATF-2(ATF2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Cyclic AMP-dependent transcription factor ATF-2(ATF2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: activating transcription factor 2
Protein Name: Cyclic AMP-dependent transcription factor ATF-2
|Purification||Immunogen affinity purified.|
|Immunogen||E.coli-derived human ATF2 recombinant protein (Position: E93-E450). Human ATF2 shares 99% amino acid (aa) sequence identity with both mouse and rat ATF2.|
Target Details ATF2Product Details anti-ATF2 Antibody Application Details Handling Images back to top
|Alternative Name||ATF2 (ATF2 Antibody Abstract)|
ATF2, also known as Activating transcription factor 2, is a protein that in humans is encoded by the ATF2 gene. It is mapped to 2q31.1. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro, thus, it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.
Synonyms: Activating Transcription Factor 2 antibody|Activating transcription factor 2 splice variant ATF2 var2 antibody|ATF 2 antibody|Atf-2 antibody|Atf2 antibody|ATF2 protein antibody|ATF2_HUMAN antibody|cAMP Response Element Binding Protein 2 antibody|cAMP response element binding protein CRE BP1 antibody|cAMP response element-binding protein CRE-BP1 antibody|cAMP responsive element binding protein 2, formerly antibody|cAMP-dependent transcription factor ATF-2 antibody|cAMP-responsive element-binding protein 2 antibody|CRE BP1 antibody|CRE-BP antibody|CREB 2 antibody|CREB-2 antibody|CREB2 antibody|CREBP1 antibody|Cyclic AMP dependent transcription factor ATF 2 antibody|Cyclic AMP-dependent transcription factor ATF-2 antibody|Cyclic AMP-responsive element-binding protein 2 antibody|D130078H02Rik antibody|D18875 antibody|HB 16 antibody|HB16 antibody|Histone acetyltransferase ATF2 antibody|MGC105211 antibody|MGC105222 antibody|MGC111558 antibody|MGC142504 antibody|mXBP antibody|MXBP protein antibody|Tg(Gzma-Klra1)7Wum antibody|TREB 7 antibody|TREB7 antibody
|Research Area||Immunology, Innate Immunity, Transcription Factors|
|Pathways||MAPK Signaling, RTK Signaling, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades|
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for ATF2 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Rat
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).
|Restrictions||For Research Use only|
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|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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