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|Antigen||Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This RPS6KA2 antibody is conjugated to HRP Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-RPS6KA2 AntibodyTarget Details RPS6KA2 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human RSK3/Ribosomal S6 kinase 3|
Target Details RPS6KA2Product Details anti-RPS6KA2 Antibody Application Details Handling Images back to top
|Alternative Name||Rsk3 (RPS6KA2 Antibody Abstract)|
RSK3(Ribosomal S6 kinase 3)is a member of a family of 90- kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
Synonyms: 90 kDa ribosomal protein S6 kinase 2, HU 2, KS6A2_HUMAN, MAP kinase activated protein kinase 1c, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, MAPKAPK1C, p90-RSK 2, p90RSK 2, p90RSK2, pp90RSK 3, pp90RSK3, Ribosomal protein S6 kinase alpha-2, Ribosomal S6 kinase 3, RPS6KA2, RSK 3, RSK-3, S6K alpha 2, S6K alpha, S6K-alpha-2.
|Research Area||Signaling, DNA/RNA|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-RPS6KA2 Antibody Target Details RPS6KA2 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-RPS6KA2 Antibody Target Details RPS6KA2 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.|
|Precaution of Use||This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|