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ACAA2 is a functional BNIP3 (show BNIP3 Proteins) binding partner and provide a possible linkage between fatty acid metabolism and apoptosis of cells.
Data show that the major mitochondrial partner of Shc (show SHC1 Proteins) adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (show HADHB Proteins) ACAA2, to which p46Shc binds directly and with a strong affinity.
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.
3-ketoacyl-CoA thiolase, mitochondrial
, acetyl-Coenzyme A acyltransferase 2
, beta ketothiolase
, mitochondrial 3-oxoacyl-CoA thiolase
, mitochondrial 3-oxoacyl-Coenzyme A thiolase
, acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
, mitochondrial acetyl-Coenzyme A acyltransferase 2
, acetyl-coenzyme A acyltransferase 2
, acetyl-CoA acyltransferase