Browse our anti-PEX5 (PEX5) Antibodies

Full name:
anti-Peroxisomal Biogenesis Factor 5 Antibodies (PEX5)
On are 44 Peroxisomal Biogenesis Factor 5 (PEX5) Antibodies from 13 different suppliers available. Additionally we are shipping PEX5 Proteins (5) and many more products for this protein. A total of 54 PEX5 products are currently listed.
AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, PXR1, X83306

Most Popular Reactivities for anti-PEX5 (PEX5) Antibodies

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anti-Mouse (Murine) PEX5 Antibodies:

anti-Rat (Rattus) PEX5 Antibodies:

anti-Human PEX5 Antibodies:

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Top referenced anti-PEX5 Antibodies

  1. Mouse (Murine) Monoclonal PEX5 Primary Antibody for IF, WB - ABIN968605 : Baes, Gressens, Baumgart, Carmeliet, Casteels, Fransen, Evrard, Fahimi, Declercq, Collen, van Veldhoven, Mannaerts: A mouse model for Zellweger syndrome. in Nature genetics 1997 (PubMed)
    Show all 4 references for 968605

  2. Cow (Bovine) Polyclonal PEX5 Primary Antibody for WB - ABIN2786512 : Maynard, Berg: Quantitative analysis of peroxisomal targeting signal type-1 binding to wild-type and pathogenic mutants of Pex5p supports an affinity threshold for peroxisomal protein targeting. in Journal of molecular biology 2007 (PubMed)

  3. Human Polyclonal PEX5 Primary Antibody for ELISA, WB - ABIN4344980 : Alencastre, Rodrigues, Grou, Fransen, Sá-Miranda, Azevedo: Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway. in The Journal of biological chemistry 2009 (PubMed)

More Antibodies against PEX5 Interaction Partners

Mouse (Murine) Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery

  2. Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice.

  3. interaction of PEX5 with catalase (show CAT Antibodies) and PEX14 (show PEX14 Antibodies)

  4. Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome (show PEX1 Antibodies), by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect

Human Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. TRIM37 (show TRIM37 Antibodies)-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder.

  2. Data suggest that soluble/cytosolic PEX5 interacts with PEX14 (show PEX14 Antibodies)/PEX13 (show PEX13 Antibodies) complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14 (show PEX14 Antibodies)/PEX13 (show PEX13 Antibodies) complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX (show PHEX Antibodies) = peroxisomal biogenesis factor)

  3. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 (show PEX14 Antibodies) and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes.

  4. our data suggest that insertion of the trimeric PEX5-PEX7 (show PEX7 Antibodies)-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix

  5. Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR (show UTS2R Antibodies) of PXR (show NR1I2 Antibodies) may be a functional biomarker to predict risk of colorectal cancer

  6. PEX5 encodes two isoforms, PEX5L (show PEX5L Antibodies) & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L (show PEX5L Antibodies)-specific exon 9, results in loss of PEX5L (show PEX5L Antibodies) only. Loss of PEX5L (show PEX5L Antibodies) results in deficient import of PTS2-tagged proteins

  7. bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity

  8. Data show that ataxia-telangiectasia mutated (ATM (show ATM Antibodies)) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species.

  9. ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import

  10. PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy

PEX5 Antigen Profile

Antigen Summary

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PEX5

  • peroxisomal biogenesis factor 5 (pex5) antibody
  • peroxisomal biogenesis factor 5 (Pex5) antibody
  • peroxisomal biogenesis factor 5 (PEX5) antibody
  • AW212715 antibody
  • ESTM1 antibody
  • PBD2A antibody
  • PBD2B antibody
  • Peroxin-5 antibody
  • PTS1-BP antibody
  • PTS1R antibody
  • PXR1 antibody
  • X83306 antibody

Protein level used designations for PEX5

peroxisome biogenesis factor 5 , PTS1 receptor , PTS1-BP , PXR1P , peroxin 5 , peroxisomal C-terminal targeting signal import receptor , peroxisomal targeting signal 1 receptor , peroxisome receptor 1 , peroxin-5 , peroxisomal targeting signal 1 (SKL type) receptor , peroxisomal targeting signal import receptor , peroxisomal targeting signal receptor 1 , PTS1R , Peroxisomal C-terminal targeting signal import receptor , Peroxisome receptor 1

496849 Xenopus (Silurana) tropicalis
19305 Mus musculus
312703 Rattus norvegicus
5830 Homo sapiens
486710 Canis lupus familiaris
514832 Bos taurus
418299 Gallus gallus
100135597 Cavia porcellus
100689015 Cricetulus griseus
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