Browse our Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (NEDD4L)

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Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (NEDD4L)
On www.antibodies-online.com are 6 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Proteins from 3 different suppliers available. Additionally we are shipping Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies (65) and many more products for this protein. A total of 76 Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like products are currently listed.
Synonyms:
1300012C07Rik, hNEDD4-2, NEDD4, Nedd4-2, NEDD4.2, Nedd4b, RSP5
list all proteins Gene Name GeneID UniProt
NEDD4L 23327 Q96PU5
Rat NEDD4L NEDD4L 291553  
NEDD4L 83814  

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Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (NEDD4L) by Origin

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More Proteins for Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Interaction Partners

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. evidence implicating E3 ubiquitin ligase (show MUL1 Proteins) NEDD4L in the pathogeny of periventricular nodular heterotopia

  2. This study demonstrated that it is possible to downregulate Kv1.3 (show KCNA3 Proteins) channel density through activation of an E3 ubiquitin ligase (show MUL1 Proteins) and that inhibition of the protease pathway or mutation of the Nedd4-2 catalytic site prevents Kv1.3 (show KCNA3 Proteins) modulation.

  3. These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (show XBP1 Proteins) and that this is important in the induction of an appropriate autophagic response.

  4. both Nedd4-1 (show NEDD4 Proteins) and Nedd4-2 are important regulators for hOAT1 (show SLC22A6 Proteins) ubiquitination, expression, and function

  5. USP36 actions extend beyond TrkA (show NTRK1 Proteins) because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Proteins)/3 channel regulation.

  6. NEDD4L negatively regulates PIK3CA (show PIK3CA Proteins) protein levels via ubiquitination and is required for the maintenance of PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling pathway.

  7. overexpression of miR (show MLXIP Proteins)-93 in lung cancer cells promoted TGF-b-induced EMT (show ITK Proteins) through downregulation of NEDD4L. The analysis of publicly available gene expression array datasets indicates that low NEDD4L expression correlates with poor outcomes among patients with lung cancer, further supporting the oncogenic role of miR (show MLXIP Proteins)-93 in lung tumorigenesis and metastasis.

  8. the regulation of Nedd4L protein expression may play a role in the development of ovarian cancers.

  9. Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2.

  10. Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Proteins) ubiquitination, and inhibited hOAT4 (show SLC22A9 Proteins) transport activity.

Xenopus laevis Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. these findings suggest that regulation of Dvl (show DVL2 Proteins) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.

  2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Proteins)-activated kinase promotes ENaC (show SCNN1A Proteins)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Proteins) by increasing Nedd4-2-dependent ENaC (show SCNN1A Proteins) retrieval from the plasma membrane.

  3. results indicate that AMPK (show PRKAA2 Proteins) inhibits KCNQ1 (show KCNQ1 Proteins) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.

  4. This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.

  5. ENaC-beta (show SCNN1B Proteins) regulation that occurs through IKKbeta (show IKBKB Proteins)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Proteins) and protein kinase A target site.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. Tmbim1 promoted the lysosomal degradation of toll-like receptor 4 (show TLR4 Proteins) by cooperating with the ESCRT endosomal sorting complex to facilitate MVB formation, and the ubiquitination of Tmbim1 by the E3 ubiquitin ligase (show MUL1 Proteins) Nedd4l was required for this process.

  2. These findings provide evidence that Nedd4-2 is up-regulated in response to endoplasmic reticulum stress by the spliced form of X-box binding protein 1 (show XBP1 Proteins) and that this is important in the induction of an appropriate autophagic response.

  3. These results identify NKCC1 (show SLC12A2 Proteins) as a novel target for Nedd4L-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Proteins)).

  4. Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Proteins)-2 (Nedd4-2)-mediated AMPA (show GRIA3 Proteins) receptor GluA1 (show GRIA1 Proteins) ubiquitination.

  5. USP36 actions extend beyond TrkA (show NTRK1 Proteins) because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 Proteins)/3 channel regulation.

  6. These findings elucidate a critical role of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  7. We identified glutamate (show GRIN1 Proteins) receptor subunit 1 (GluA1 (show GRIA1 Proteins)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2

  8. The short isoform of the ubiquitin ligase (show RNF123 Proteins) NEDD4L is a CREB (show CREB1 Proteins) target gene in hepatocytes.

  9. Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Proteins) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  10. The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.

Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Protein Profile

Protein Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L)

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L)
  • NEDD4L (LOC776799)
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (nedd4l)
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l)
  • neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l)
  • 1300012C07Rik protein
  • hNEDD4-2 protein
  • NEDD4 protein
  • Nedd4-2 protein
  • NEDD4.2 protein
  • Nedd4b protein
  • RSP5 protein

Protein level used designations for NEDD4L

E3 ubiquitin-protein ligase NEDD4-like , E3 ubiquitin-protein ligase NEDD4-like protein , ubiquitin-protein ligase Rsp5 , neural precursor cell expressed, developmentally down-regulated 4 , NEDD4.2 , neural precursor cell expressed, developmentally down-regulated gene 4b

GENE ID SPECIES
100054395 Equus caballus
100172429 Pongo abelii
776799 Gallus gallus
23327 Homo sapiens
399396 Xenopus laevis
510003 Bos taurus
291553 Rattus norvegicus
100512083 Sus scrofa
476189 Canis lupus familiaris
83814 Mus musculus
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