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we identified the ANN complex as a novel functional module supporting the nucleolar maturation of 40S ribosomal subunits. Our data help to explain the described role of AATF in cell proliferation during mouse development as well as its requirement for malignant tumor growth.
the effect of APOBEC3G (show APOBEC3G ELISA Kits) over-expression upon AATF gene expression, was examined.
loss of Che-1 (show BCHE ELISA Kits) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 (show TP53 ELISA Kits)
It was concluded that PARP-1 (show PARP1 ELISA Kits) was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation.
These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy.
In the face of high glucose threat, mitochondrial UCP2 (show UCP2 ELISA Kits) gene expression is regulated by miR (show MLXIP ELISA Kits)-2909 and AATF.
This mutant AATF along with its interactome consisting of SP1 (show PSG1 ELISA Kits), DNMT3B (show DNMT3B ELISA Kits) and Par-4 (show PAWR ELISA Kits) ensures cancer cell DNA methylation (show HELLS ELISA Kits) required for down-regulation of tumor suppressor genes.
HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation.
Che-1 (show BCHE ELISA Kits) expression correlates with the progression of multiple myeloma and is required for cell growth and survival.Che-1 controls mTOR (show FRAP1 ELISA Kits) through the induction of Redd1 (show DDIT4 ELISA Kits) and Deptor (show DEPTOR ELISA Kits), two important repressors of mTOR (show FRAP1 ELISA Kits).
Cell proliferation decreased by 41% which was accompanied by apoptosis induction in 30% MCF-7 cells after AATF gene knockdown.
These results identify AATF as a nucleolar-confined c-Jun (show JUN ELISA Kits) cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun (show JUN ELISA Kits) and the levels of c-Jun (show JUN ELISA Kits)-mediated apoptosis.
AATF is an endogenous antagonist of Par-4 (show F2RL3 ELISA Kits) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Che-1 as a new Pin1 (show PIN1 ELISA Kits) and HDM2 target and confirm its important role in the cellular response to DNA damage.
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
apoptosis antagonizing transcription factor
, protein AATF
, Apoptosis antagonizing transcription factor
, protein AATF-like
, apoptosis-antagonizing transcription factor
, rb-binding protein Che-1
, traube protein