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cells deficient in acid ceramidase (aCDase (show ASAH1 ELISA Kits)) also exhibited defects in CCL5 (show CCL5 ELISA Kits) induction, whereas cells deficient in sphingosine kinase-1 (show SPHK1 ELISA Kits) and -2 exhibited higher levels of CCL5 (show CCL5 ELISA Kits).
nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure
Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. (nSMase 1)
NSMase-2 could be involved in IL-1beta (show IL1B ELISA Kits)-induced JNK (show MAPK8 ELISA Kits) activation in hepatocytes
Nuclear sphingomyelin-synthase and protein kinase C delta (show PKCd ELISA Kits) are expressed in melanoma cells
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase (show ASAH1 ELISA Kits) have roles in cutaneous aging
Peptidoglycan activates the nSMase/ceramide pathway to induce MKK3 (show MAP2K3 ELISA Kits)/6/p38 MAPK (show MAPK14 ELISA Kits) activation, which in turn initiates NF-kappaB (show NFKB1 ELISA Kits) activation and ultimately induces COX-2 (show COX2 ELISA Kits) expression in macrophages.
Interestingly, neutral but not acid sphingomyelinase (show SMPD1 ELISA Kits) was mandatory for PorBIA -mediated Neisseria gonorrhoeae invasion into host cells.
nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2)has a common central role in ceramide signaling during the stress and cytokine responses and apoptosis.
These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK (show MAPK14 ELISA Kits), leading to apoptosis in vascular smooth muscle cells, which initiates VSMC calcification.
N-SMase at the cytofacial plasma membrane is an essential element for the proper orientation of PMNs in FMLP (show FPR1 ELISA Kits) gradients, at least in part by polarizing the distribution of Rac 1/2 and RhoA (show RHOA ELISA Kits) GTPases.
Results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK (show MAPK8 ELISA Kits) and p38MAPK (show MAPK14 ELISA Kits) and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients.
Data show DA remarkably increased the NSMase2 message and protein, whereas little change in NSMase1 and NSMase3 (show SMPD4 ELISA Kits) mRNAs.
nSMase2 functions as a growth suppressor in MCF7 cells, linking confluence to the G(0)/G(1) cell cycle check point.
identification of 15 polymorphisms, including 9 novel SNPs, in the SMPD2 gene; one haplotype showed associations with the extrinsic type of atopic dermatitis subgroup
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
, Mg2+-dependent neutral sphingomyelinase
, neutral SMase I
, neutral sphingomyelinase
, sphingomyelin phosphodiesterase 2
, sphingomyelin phosphodiesterase 2-like
, lyso-platelet-activating factor-phospholipase C
, neutral sphingomyelinase 1