anti-Human EGFR antibody for Biochemical Assay

Recommended EGFR Antibody (supplied by: Log in to see )

Antigen
Epidermal Growth Factor Receptor (EGFR) Antibodies
  • C-erb
  • CG10079
  • D-EGFR
  • D-Egf
  • DEGFR
  • DER
  • DER flb
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DEgfr
  • Degfr
  • Der
  • DmHD-33
  • Dmel\\CG10079
  • EFG-R
  • EGF-R
  • EGFR
  • EGFr
  • EGfr
  • EK2-6
  • Egf
  • Egf-r
  • EgfR
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • HD-33
  • TOP
  • Torpedo/DER
  • Torpedo/Egfr
  • c-erbB
  • d-egf-r
  • dEGFR
  • dEGFR1
  • dEgfr
  • der
  • egfr
  • flb
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57EFa
  • l(2)57Ea
  • mor1
  • top
  • top/DER
  • top/flb
  • torpedo/Egfr
  • torpedo/egfr
  • EGFR12
  • EGFR15
  • egfr1
  • Erbb2
  • ERBB
  • ERBB1
  • HER1
  • PIG61
  • mENA
  • ErbB-1
  • Errp
  • 9030024J15Rik
  • AI552599
  • Erbb
  • Errb1
  • Wa5
  • wa-2
  • wa2
  • epidermal growth factor receptor
  • Epidermal growth factor receptor
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • EGFR
  • Egfr
  • egfra
  • egfr1
  • AaeL_AAEL004319
  • LOC100008806
Epitope
pTyr1068
147
138
64
64
60
58
57
54
54
53
49
49
43
38
36
33
30
29
29
27
26
25
25
23
22
19
19
18
18
16
16
16
16
15
15
15
15
15
14
14
13
11
9
9
8
8
8
7
6
6
6
6
5
5
5
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
2416
865
699
29
24
18
17
15
15
6
3
2
2
2
1
1
1
Host
Rabbit
1457
857
81
44
9
3
2
1
1
Clonality
Polyclonal
Conjugate
This EGFR antibody is un-conjugated
102
80
71
63
56
54
32
32
28
28
28
28
28
28
27
26
26
25
25
24
24
21
21
21
21
21
20
19
18
2
2
2
1
Application
Biochemical Assay (BCA)
1445
678
615
555
508
272
260
229
124
84
66
56
40
24
19
14
12
11
7
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN2666246
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General

Antigen Epidermal Growth Factor Receptor (EGFR) Antibodies
Epitope pTyr1068
(147), (138), (64), (64), (60), (58), (57), (54), (54), (53), (49), (49), (43), (38), (36), (33), (30), (29), (29), (27), (26), (25), (25), (23), (22), (19), (19), (18), (18), (16), (16), (16), (16), (15), (15), (15), (15), (15), (14), (14), (13), (11), (9), (9), (8), (8), (8), (7), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(2416), (865), (699), (29), (24), (18), (17), (15), (15), (6), (3), (2), (2), (2), (1), (1), (1)
Host Rabbit
(1457), (857), (81), (44), (9), (3), (2), (1), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This EGFR antibody is un-conjugated
(102), (80), (71), (63), (56), (54), (32), (32), (28), (28), (28), (28), (28), (28), (27), (26), (26), (25), (25), (24), (24), (21), (21), (21), (21), (21), (20), (19), (18), (2), (2), (2), (1)
Application Biochemical Assay (BCA)
(1445), (678), (615), (555), (508), (272), (260), (229), (124), (84), (66), (56), (40), (24), (19), (14), (12), (11), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-EGFR Antibody

Target Details EGFR Application Details Handling ProductDetails: References for anti-EGFR antibody (ABIN2666246) Images
Clone Poly6563
Isotype IgG

Target Details EGFR

Product Details anti-EGFR Antibody Application Details Handling ProductDetails: References for anti-EGFR antibody (ABIN2666246) Images back to top
Antigen
Alternative Name EGFR (EGFR Antibody Abstract)
Background EGFR is a transmembrane glycoprotein that belongs to protein kinase superfamily. It is expressed in tissues of epithelial, mesenchymal and neuronal origin and plays major roles in proliferation, differentiation and development. Binding of the protein to its ligand induces receptor dimerization and tyrosine autophosphorylation. Mutations or over-expression of this gene are associated with certain forms of cancer. Tyrosine 1068 is the primary autophosphorylation site in the C-terminal domain of the receptor.
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation

Application Details

Product Details anti-EGFR Antibody Target Details EGFR Handling ProductDetails: References for anti-EGFR antibody (ABIN2666246) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-EGFR Antibody Target Details EGFR Application Details ProductDetails: References for anti-EGFR antibody (ABIN2666246) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt, store undiluted at -20°C.

ProductDetails: References for anti-EGFR antibody (ABIN2666246)

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling Images back to top
Background publications

Alameddine, Otrock, Awada, Shamseddine: "Crosstalk between HER2 signaling and angiogenesis in breast cancer: molecular basis, clinical applications and challenges." in: Current opinion in oncology, Vol. 25, Issue 3, pp. 313-24, 2013

Hrustanovic, Lee, Bivona: "Mechanisms of resistance to EGFR targeted therapies." in: Cancer biology & therapy, Vol. 14, Issue 4, pp. 304-14, 2013

Wheeler, Siwak, Chai, LaValle, Seethala, Wang, Cieply, Sherer, Joy, Mills, Argiris, Siegfried, Grandis, Egloff: "Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 8, pp. 2278-89, 2012

Yano, Kondo, Yamaguchi, Richmond, Hutchison, Wakeling, Averbuch, Wadsworth: "Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition." in: Anticancer research, Vol. 23, Issue 5A, pp. 3639-50, 2003

Koland, OBrien, Cerione: "Expression of epidermal growth factor receptor sequences as E. coli fusion proteins: applications in the study of tyrosine kinase function." in: Biochemical and biophysical research communications, Vol. 166, Issue 1, pp. 90-100, 1990

Images

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling ProductDetails: References for anti-EGFR antibody (ABIN2666246) back to top
Supplier Images
Western Blotting (WB) image for anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1068) antibody (ABIN2666246) anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1068) antibody