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anti-Human EGFR antibody for Biochemical Assay

Recommended EGFR Antibody (supplied by: Log in to see )

Antigen
Epidermal Growth Factor Receptor (EGFR) Antibodies
  • 9030024J15Rik
  • AI552599
  • C-erb
  • c-erbB
  • CG10079
  • D-Egf
  • d-egf-r
  • D-EGFR
  • Degfr
  • dEgfr
  • DEgfr
  • DEGFR
  • dEGFR
  • dEGFR1
  • der
  • DER
  • Der
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DER flb
  • Dmel\\CG10079
  • DmHD-33
  • EFG-R
  • Egf
  • EGF-R
  • Egf-r
  • EgfR
  • EGfr
  • EGFr
  • EGFR
  • egfr
  • egfr1
  • EGFR12
  • EGFR15
  • EK2-6
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • ERBB
  • Erbb
  • ErbB-1
  • ERBB1
  • Erbb2
  • Errb1
  • Errp
  • flb
  • HD-33
  • HER1
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57Ea
  • l(2)57EFa
  • mENA
  • mor1
  • PIG61
  • TOP
  • top
  • top/DER
  • top/flb
  • Torpedo/DER
  • Torpedo/Egfr
  • torpedo/Egfr
  • torpedo/egfr
  • wa-2
  • wa2
  • Wa5
Epitope
pTyr1068
127
56
55
52
51
49
48
45
45
44
44
33
32
30
30
25
23
23
23
22
21
19
18
17
16
16
14
13
13
13
13
13
13
13
13
11
10
10
10
9
9
9
8
8
8
8
8
7
7
6
6
6
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1700
662
590
21
14
14
12
10
7
7
4
2
1
1
1
Host
Rabbit
1263
393
36
25
4
2
Clonality
Polyclonal
Conjugate
This EGFR antibody is un-conjugated
74
57
45
35
25
25
23
22
21
21
21
21
21
21
20
2
2
1
Application
Biochemical Assay (BCA)
1103
500
380
240
232
205
175
142
86
60
55
54
25
11
9
5
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2666246
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Top referenced anti-EGFR antibody for Biochemical Assay

Similar anti-EGFR Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 1 Antibodies
Blocking Antibody (Inhibition) 3 Antibodies
Blocking Reagent (BR) 9 Antibodies
Cell-ELISA (cELISA) 1 Antibodies
Cellular Assay (CA) 1 Antibodies
Dot Blot (DB) 86 Antibodies
ELISA 492 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 55 Antibodies
Flow Cytometry (FACS) 180 Antibodies
Fluorescence Microscopy (FM) 1 Antibodies
Functional Studies (Func) 2 Antibodies
Immunoassay (IA) 1 Antibodies
Immunochromatography (IC) 25 Antibodies
Immunocytochemistry (ICC) 67 Antibodies
Immunoelectron Microscopy (IEM) 2 Antibodies
Immunofluorescence (IF) 151 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 232 Antibodies

General

Antigen Epidermal Growth Factor Receptor (EGFR) Antibodies
Epitope pTyr1068
(127), (56), (55), (52), (51), (49), (48), (45), (45), (44), (44), (33), (32), (30), (30), (25), (23), (23), (23), (22), (21), (19), (18), (17), (16), (16), (14), (13), (13), (13), (13), (13), (13), (13), (13), (11), (10), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (7), (6), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(1700), (662), (590), (21), (14), (14), (12), (10), (7), (7), (4), (2), (1), (1), (1)
Host Rabbit
(1263), (393), (36), (25), (4), (2)
Clonality (Clone)
Polyclonal   ( )
Conjugate This EGFR antibody is un-conjugated
(74), (57), (45), (35), (25), (25), (23), (22), (21), (21), (21), (21), (21), (21), (20), (2), (2), (1)
Application Biochemical Assay (BCA)
(1103), (500), (380), (240), (232), (205), (175), (142), (86), (60), (55), (54), (25), (11), (9), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-EGFR Antibody

Target Details EGFR Application Details Handling References for anti-EGFR Antibody (ABIN2666246) Images
Clone Poly6563
Isotype IgG

Target Details EGFR

Product Details anti-EGFR Antibody Application Details Handling References for anti-EGFR Antibody (ABIN2666246) Images back to top
Antigen
Alternative Name EGFR (EGFR Antibody Abstract)
Background EGFR is a transmembrane glycoprotein that belongs to protein kinase superfamily. It is expressed in tissues of epithelial, mesenchymal and neuronal origin and plays major roles in proliferation, differentiation and development. Binding of the protein to its ligand induces receptor dimerization and tyrosine autophosphorylation. Mutations or over-expression of this gene are associated with certain forms of cancer. Tyrosine 1068 is the primary autophosphorylation site in the C-terminal domain of the receptor.
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-EGFR Antibody Target Details EGFR Handling References for anti-EGFR Antibody (ABIN2666246) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-EGFR Antibody Target Details EGFR Application Details References for anti-EGFR Antibody (ABIN2666246) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt, store undiluted at -20°C.

References for anti-EGFR Antibody (ABIN2666246)

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling Images back to top
Background publications

Alameddine, Otrock, Awada, Shamseddine: "Crosstalk between HER2 signaling and angiogenesis in breast cancer: molecular basis, clinical applications and challenges." in: Current opinion in oncology, Vol. 25, Issue 3, pp. 313-24, 2013

Hrustanovic, Lee, Bivona: "Mechanisms of resistance to EGFR targeted therapies." in: Cancer biology & therapy, Vol. 14, Issue 4, pp. 304-14, 2013

Wheeler, Siwak, Chai, LaValle, Seethala, Wang, Cieply, Sherer, Joy, Mills, Argiris, Siegfried, Grandis, Egloff: "Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 8, pp. 2278-89, 2012

Yano, Kondo, Yamaguchi, Richmond, Hutchison, Wakeling, Averbuch, Wadsworth: "Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition." in: Anticancer research, Vol. 23, Issue 5A, pp. 3639-50, 2003

Koland, OBrien, Cerione: "Expression of epidermal growth factor receptor sequences as E. coli fusion proteins: applications in the study of tyrosine kinase function." in: Biochemical and biophysical research communications, Vol. 166, Issue 1, pp. 90-100, 1990

Images

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling References for anti-EGFR Antibody (ABIN2666246) back to top
Supplier Images
Western Blotting (WB) image for anti-EGFR antibody (Epidermal Growth Factor Receptor) (pTyr1068) (ABIN2666246) anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1068) antibody