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anti-Human IL1B antibody for Immunohistochemistry

Recommended IL1B Antibody (supplied by: Log in to see )

Antigen
Interleukin 1, beta (IL1B) Antibodies
  • il1-b
  • zgc:111873
  • IL-1beta
  • Il-1b
  • IL1B
  • IL-1
  • IL1-BETA
  • IL1F2
  • IL-1BETA
  • IL1beta
  • IL-1B
  • interleukin 1, beta
  • interleukin 1 beta
  • il1b
  • Il1b
  • IL-1B
  • IL1B
Epitope
N-Term
30
25
25
23
18
16
15
12
11
10
9
7
7
6
6
5
5
5
5
5
5
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
532
179
128
39
31
22
18
17
12
11
8
7
7
4
3
2
2
2
1
1
Host
Rabbit
408
351
17
16
8
8
6
3
2
Clonality
Polyclonal
Conjugate
This IL1B antibody is un-conjugated
100
48
35
22
13
12
11
10
8
8
8
8
8
8
8
8
8
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
539
434
175
126
110
74
59
58
38
29
25
24
14
14
13
7
5
4
4
3
3
3
2
2
1
1
1
1
1
1
1
Options
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Catalog No. ABIN2785655
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
8.72946 ABIN5326748 IHC WB Rabbit N-Term Log in to see Polyclonal 1
8.72946 ABIN969215 ICC IHC ELISA WB Mouse IgG1 Log in to see 3A6 2
8.72946 ABIN446969 IHC (p) IHC WB Rabbit Internal Region Log in to see Polyclonal 3
8.72946 ABIN269770 ELISA EM ICC IF IHC IHC (p) IP WB Rabbit N-Term Log in to see Polyclonal 9
8.72946 ABIN1536091 IHC ELISA Rabbit IgG Cleaved-Asp210 Log in to see Polyclonal
8.72946 ABIN1536090 IHC ELISA WB Rabbit IgG Cleaved-Asp210 Log in to see Polyclonal
8.72946 ABIN2706371 IHC WB Rabbit Center Log in to see Polyclonal
8.72946 ABIN4324389 IF IHC WB Mouse IgG1 Log in to see 3E1
8.72946 ABIN3031434 FACS IHC ELISA WB Rabbit Ig Fraction AA 148-174 Log in to see Polyclonal
8.72946 ABIN3031433 FACS IHC ELISA WB Rabbit Ig Fraction AA 177-206 Log in to see Polyclonal
8.72946 ABIN2428273 IHC ELISA WB Rabbit IgG Log in to see Polyclonal
8.72946 ABIN2487916 FACS IHC ELISA WB Rabbit Ig Fraction Log in to see Polyclonal
8.72946 ABIN1845349 ELISA IF/ICC IHC WB Mouse IgG1 Log in to see
1 ABIN1582289 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal 3
1 ABIN964768 FACS IP IHC Neut RIA ELISA WB HRP Rabbit IgG N-Term, Cleavage Site Log in to see Polyclonal
1 ABIN3185165 ELISA IHC WB Rabbit IgG Internal Region Log in to see Polyclonal
1 ABIN964752 FACS IP IHC Neut RIA ELISA WB Rabbit IgG N-Term, Cleavage Site Log in to see Polyclonal
1 ABIN1102520 FACS IHC ELISA WB HRP Rabbit IgG Log in to see Polyclonal
1 ABIN964777 FACS IP IHC Neut RIA ELISA WB Biotin Rabbit IgG N-Term, Cleavage Site Log in to see Polyclonal
1 ABIN1873201 IHC WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-IL1B antibody for Immunohistochemistry

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Application / Reactivity Human
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General

Antigen Interleukin 1, beta (IL1B) Antibodies
Epitope N-Term
(30), (25), (25), (23), (18), (16), (15), (12), (11), (10), (9), (7), (7), (6), (6), (5), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(532), (179), (128), (39), (31), (22), (18), (17), (12), (11), (8), (7), (7), (4), (3), (2), (2), (2), (1), (1)
Host Rabbit
(408), (351), (17), (16), (8), (8), (6), (3), (2)
Clonality
Polyclonal
Conjugate This IL1B antibody is un-conjugated
(100), (48), (35), (22), (13), (12), (11), (10), (8), (8), (8), (8), (8), (8), (8), (8), (8), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(539), (434), (175), (126), (110), (74), (59), (58), (38), (29), (25), (24), (14), (14), (13), (7), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-IL1B Antibody

Target Details IL1B Application Details Handling References for anti-IL1B Antibody (ABIN2785655) Images
Blocking Peptide Blocking peptide for this product available: ABIN978486
Sequence DLDLCPLDGG IQLRISDHHY SKGFRQAASV VVAMDKLRKM LVPCPQTFQE
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against IL1B. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human IL1B

Target Details IL1B

Product Details anti-IL1B Antibody Application Details Handling References for anti-IL1B Antibody (ABIN2785655) Images back to top
Antigen
Alternative Name IL1B (IL1B Antibody Abstract)
Background IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Molecular Weight 17 kDa
Gene ID 3553
NCBI Accession NM_000576, NP_000567
UniProt P01584
Pathways NF-kappaB Signaling, TCR Signaling, Interferon-gamma Pathway, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity

Application Details

Product Details anti-IL1B Antibody Target Details IL1B Handling References for anti-IL1B Antibody (ABIN2785655) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 153 AA

Restrictions For Research Use only

Handling

Product Details anti-IL1B Antibody Target Details IL1B Application Details References for anti-IL1B Antibody (ABIN2785655) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment For short term use, store at 2-8 °C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-IL1B Antibody (ABIN2785655)

Product Details anti-IL1B Antibody Target Details IL1B Application Details Handling Images back to top
Background publications

Piccini, Carta, Tassi, Lasiglié, Fossati, Rubartelli: "ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 23, pp. 8067-72, 2008

Images

Product Details anti-IL1B Antibody Target Details IL1B Application Details Handling References for anti-IL1B Antibody (ABIN2785655) back to top
Supplier Images
Western Blotting (WB) image for anti-IL1B antibody (Interleukin 1, beta) (N-Term) (ABIN2785655) WB Suggested Anti-IL1B Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Immunohistochemistry (IHC) image for anti-IL1B antibody (Interleukin 1, beta) (N-Term) (ABIN2785655) Sample Type: Human Macrophange Cells
Green: primary
Red: p...