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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||218 Antibodies||91 Antibodies||41 Antibodies|
|SDS-PAGE (SDS)||1 Antibodies||1 Antibodies||1 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies||1 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||36 Antibodies||16 Antibodies||11 Antibodies|
|Immunohistochemistry (IHC)||59 Antibodies||29 Antibodies||18 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies||2 Antibodies||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||2 Antibodies|
|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of MyD88 protein. (region surrounding Val220)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Affinity chromatography using epitope-specific immunogen|
|Purity||> 95 % (by SDS-PAGE)|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling Images back to top
|Alternative Name||MYD88 (MYD88 Antibody Abstract)|
|Background||Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptorassociated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophili,a and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.Synonyms: Myeloid differentiation primary response protein MyD88|
|Molecular Weight||approx. 35 kDa|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling Images back to top
Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling back to top