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Browse our NFKBIZ Proteins (NFKBIZ)

Full name:
Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta Proteins (NFKBIZ)
On www.antibodies-online.com are 3 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ) Proteins from 2 different suppliers available. Additionally we are shipping NFKBIZ Antibodies (37) and NFKBIZ Kits (3) and many more products for this protein. A total of 44 NFKBIZ products are currently listed.
Synonyms:
AA408868, IKBZ, INAP, Mail, NFKBIZ, RGD1310834
list all proteins Gene Name GeneID UniProt
Rat NFKBIZ NFKBIZ 304005  
NFKBIZ 80859 Q9EST8
NFKBIZ 64332 Q9BYH8

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NFKBIZ Proteins (NFKBIZ) by Origin

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Mouse (Murine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ) interaction partners

  1. A possible important role of Nfkbiz in modulating the progression of inflammatory diseases in which IFN-gamma (show IFNG Proteins) and IL-1 (show IL1A Proteins) are abundant.

  2. Nfkbiz-/- keratinocytes were hypoproliferative. In skin from Nfkbiz-/- mice, the expression of the keratinocyte differentiation markers K10 (show KRT10 Proteins) and filaggrin (show FLG Proteins) were reduced, although that of K14 (show KRT14 Proteins) was unchanged.

  3. These data reveal a previously unappreciated role for IkappaB-zeta in IFN-gamma (show IFNG Proteins) production in T cells and the immunoregulatory function of T regulatory cells.

  4. The pyrimidine-rich IkappaBzeta-responsive site plays an essential role in productive interaction of IkappaBzeta with the p50 (show LSP1 Proteins)-DNA complex.

  5. IkappaB-zeta regulates TLR-mediated CSR by inducing AID

  6. The IkappaB-zeta-Akirin2 (show AKIRIN2 Proteins)-BAF60 complex physically links the NF-kappaB (show NFKB1 Proteins) and SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes in innate immune cell activation.

  7. The IkappaB-zeta-deficient B cells exhibited impaired proliferation and enhanced up-regulation of CD86 (show CD86 Proteins) following stimulation of TLR9 (show TLR9 Proteins), but not the BCR (show BCR Proteins), indicating critical roles for IkappaB-zeta in TLR signaling in B cells.

  8. IkappaBzeta-deficient mice showed significantly impaired CCL2 (show CCL2 Proteins) secretion.

  9. Data indicate that expression of IkappaB-zeta in the lacrimal gands requires STAT3 (show STAT3 Proteins).

  10. extracellular signal regulated kinases modulate IL-12 (show IL12A Proteins) expression by regulating IkappaB-zeta-dependent binding of NF-kappaB (show NFKB1 Proteins) transcription factors to IL-12b (show IL12B Proteins) gene promoter

Human Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ) interaction partners

  1. We propose a previously unappreciated role of IkappaBzeta in the inflammatory micromilieu as well as progression in glioma

  2. These results indicate that the LPS (show IRF6 Proteins)/IL-1beta (show IL1B Proteins)-MyD88 (show MYD88 Proteins) axis plays a crucial role for stabilization of IkappaB-zeta mRNA.

  3. Interferon-gamma (IFN-gamma (show IFNG Proteins)) interferes with the IL-1 (show IL1A Proteins)/IKB-zeta axis in beta-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFN-gamma (show IFNG Proteins) and IL-22 (show IL22 Proteins).

  4. NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b (show IL1B Proteins)-induced IL-6 (show IL6 Proteins) and GMCSF (show CSF2 Proteins).

  5. IkappaBzeta functions as an important regulator of IFN-gamma (show IFNG Proteins) in human NK cells

  6. NF-kappaB (show NFKB1 Proteins)-binding cofactor inhibitor of NF-kappaB (show NFKB1 Proteins)-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax (show CNTN2 Proteins) transactivates the IkappaB-zeta gene, mainly through NF-kappaB (show NFKB1 Proteins).

  7. our data demonstrate that IkappaB-zeta is essential for nuclear NF-kappaB (show NFKB1 Proteins) activity in activated B-cell-like subtype of diffuse large B-cell lymphoma

  8. investigation of signaling components that induce activation of post-transcriptional mechanism for IkappaB-zeta induction/activation: Activation of IRAK1 (show IRAK1 Proteins) or IRAK4 (show IRAK4 Proteins), but not TRAF6 (show TRAF6 Proteins), is sufficient.

  9. analysis of the sequence of flagellin (show FliC Proteins)/TLR5 (show TLR5 Proteins)- and type IV-dependent IkappaBzeta expression, recruitment of IkappaBzeta/p50 (show CD40 Proteins) to the il6 (show IL6 Proteins) promoter, chromatin remodelling and subsequent IL-6 (show IL6 Proteins) transcription in L. pneumophila-infected lung epithelial cells

  10. conclude that multiple NFKBIZ polymorphisms associate with susceptibility to IPD in humans. The study of multiple populations may aid in fine mapping of associations within extensive regions of strong linkage disequilibrium

NFKBIZ Protein Profile

Protein Summary

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NFKBIZ

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (Nfkbiz)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (nfkbiz)
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (LOC100356473)
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta (Nfkbiz)
  • AA408868 protein
  • IKBZ protein
  • INAP protein
  • Mail protein
  • NFKBIZ protein
  • RGD1310834 protein

Protein level used designations for NFKBIZ

IkappaB-zeta , NF-kappa-B inhibitor zeta , nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta , molecule associated with ankyrin repeats induced by lipopolysaccharide , NF-kappa-B inhibitor zeta-like , I-kappa-B-zeta , IL-1 inducible nuclear ankyrin-repeat protein , ikB-zeta , ikappaBzeta , molecule possessing ankyrin repeats induced by lipopolysaccharide , molecule possessing ankyrin-repeats induced by lipopolysaccharide , Ikappa B-zeta variant 3 , molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse

GENE ID SPECIES
304005 Rattus norvegicus
418404 Gallus gallus
460564 Pan troglodytes
478549 Canis lupus familiaris
702846 Macaca mulatta
100001781 Danio rerio
100012533 Monodelphis domestica
100034245 Equus caballus
100089070 Ornithorhynchus anatinus
100170483 Xenopus (Silurana) tropicalis
100356473 Oryctolagus cuniculus
100456330 Pongo abelii
100562077 Anolis carolinensis
100597177 Nomascus leucogenys
80859 Mus musculus
64332 Homo sapiens
282713 Bos taurus
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