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|Antigen||TNFRSF1A-Associated Via Death Domain (TRADD) Antibodies|
|Epitope||AA 163-312 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This TRADD antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TRADD AntibodyTarget Details TRADD Application Details Handling References for anti-TRADD antibody (ABIN968046) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human TRADD aa. 163-312|
Target Details TRADDProduct Details anti-TRADD Antibody Application Details Handling References for anti-TRADD antibody (ABIN968046) Images back to top
|Alternative Name||TRADD (TRADD Antibody Abstract)|
TNFalpha (Tumor Necrosis Factor) stimulates programmed cell death and NF-kappaB activation as a result of its binding to the TNF receptor 1 (TNFR1). Within this receptor, a sequence referred to as the death domain” has been shown to be necessary for both of these functions. Using the yeast two-hybrid system to detect proteins which interact with the receptor through this death domain”, a 34 kDa protein was found and designated TRADD (TNFR1-Associated Death Domain protein). TRADD appears to contain no intrinsic catalytic activity. It also contains a death domain and it has been shown to bind to FADD and RIP. Mutational analysis of TRADD demonstrates that programmed cell death and NF-kappaB activation are distinct and controlled independently.
Synonyms: TNFR1-Associated Death Domain protein
|Molecular Weight||34 kDa|
|Research Area||Cardiovascular, Atherosclerosis, Apoptosis/Necrosis|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C|
Application DetailsProduct Details anti-TRADD Antibody Target Details TRADD Handling References for anti-TRADD antibody (ABIN968046) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRADD Antibody Target Details TRADD Application Details References for anti-TRADD antibody (ABIN968046) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
References for anti-TRADD antibody (ABIN968046)Product Details anti-TRADD Antibody Target Details TRADD Application Details Handling Images back to top
|Product cited in:||
He, Ting: "A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6034-45, 2002
Morgan, Thorburn, Pandolfi, Thorburn: "Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms." in: The Journal of cell biology, Vol. 157, Issue 6, pp. 975-84, 2002
Yount, Afshar, Ries, Korn, Shalev, Basila, McCormick, Haas-Kogan: "Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells." in: Oncogene, Vol. 20, Issue 22, pp. 2826-35, 2001
Park, Baichwal: "Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD." in: The Journal of biological chemistry, Vol. 271, Issue 16, pp. 9858-62, 1996
Hsu, Xiong, Goeddel: "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation." in: Cell, Vol. 81, Issue 4, pp. 495-504, 1995
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