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|Antigen||TNF Receptor-Associated Factor 2 (TRAF2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRAF2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TRAF2 AntibodyTarget Details TRAF2 Application Details Handling Images
|Specificity||This antibody detects TRAF2 at C-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Peptide affinity chromatography|
|Immunogen||TRAF2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TRAF2.|
Target Details TRAF2Product Details anti-TRAF2 Antibody Application Details Handling Images back to top
|Alternative Name||TRAF2 / TRAP3 (TRAF2 Antibody Abstract)|
|Background||Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress (1). TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity (2), and are critical for NF-kappaB activation in mouse B lymphocytes (3). TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells (4). TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac (5).Synonyms: TNF receptor-associated factor 2, Tumor necrosis factor type 2 receptor-associated protein 3|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C|
Application DetailsProduct Details anti-TRAF2 Antibody Target Details TRAF2 Handling Images back to top
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRAF2 Antibody Target Details TRAF2 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|