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A novel role for the really interesting new gene-domain E3 ubiquitin ligase (show MUL1 Proteins) deltex-3-like (DTX3L) in regulating CXCR4 (show CXCR4 Proteins) sorting from endosomes to lysosomes.
The present study further suggests that the combined targeted inhibition of STAT1 (show STAT1 Proteins), ARTD8, ARTD9 and/or DTX3L could increase the efficacy of chemotherapy or radiation treatment in prostate and other high-risk tumor types with an increased STAT1 (show STAT1 Proteins) signaling.
Data establish that BAL1 and BBAP are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair.
we report the high-resolution crystal structure of this previously uncharacterized C-terminal domain of human DTX3L, which we term the Deltex (show DTX1 Proteins) C-terminal domain.
BAL1 and BBAP are located on chromosome 3q21 in a head-to-head orientation and are regulated by a IFN-gamma (show IFNG Proteins)-responsive bidirectional promoter.
Overexpression of DTX3L, PIK3R4, ATP2C1, and SLC25A36, all located at 3q21.1-23 are associated with cervical cancer.
Data directly implicate BBAP in the monoubiquitylation and additional posttranslational modification of histone H4 and an associated DNA damage response.
It is reported that BBAP and the human family of DTX (show DTX1 Proteins) proteins (DTX1 (show DTX1 Proteins), DTX2 (show DTX2 Proteins), and DTX3 (show DTX3 Proteins)) function as E3 ligases based on their capacity for self-ubiquitination.
Data indicate that PARP (show PARP1 Proteins) polymerase PARP9-E3 ligase DTX3L interacts with STAT1 (show STAT1 Proteins) transcription factor and enhances translocation of STAT1 (show STAT1 Proteins) to the nucleus.
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003
E3 ubiquitin-protein ligase DTX3L
, deltex 3-like (Drosophila)
, E3 ubiquitin-protein ligase DTX3L-like
, e3 ubiquitin-protein ligase DTX3L-like
, deltex 3-like
, protein deltex-3-like
, B-lymphoma- and BAL-associated protein
, rhysin 2