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Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
Jag1 (show JAG1 ELISA Kits)/fringe genes (Lfng (show LFNG ELISA Kits), Rfng, and Mfng (show MFNG ELISA Kits)) may regulate postnatal bile duct growth and remodeling, and serve as candidate modifiers of the hepatic phenotype in Alagille syndrome.
inhibits Notch effector Hes1 mRNA expression; may inhibit Notch signaling in postmitotic neurons
, beta-1,3-N-acetylglucosaminyltransferase radical fringe
, radical fringe homolog
, radical fringe gene homolog