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Human NR3C1 ELISA Kit for Cell ELISA - ABIN2685094
Mortiboys, Aasly, Bandmann: Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease. in Brain : a journal of neurology 2013
The potentiation of RANKL (show TNFSF11 ELISA Kits) induced CTX release by dexamethasone was significantly less in bone marrow macrophage cells from mice with conditional knockout of the osteoclastic glucocorticoid receptor and completely absent in cells from GR(dim) mice, which carry a point mutation in one dimerizing interface of the GC receptor.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 ELISA Kits) cochaperone activity of FKBP51 (show FKBP5 ELISA Kits) with a functional impact on GR signaling in a neuronal context.
These results together suggested that ERK1 (show MAPK3 ELISA Kits) phosphorylation plays a critical role in regulating GR beta expression and hydrocortisone-induce GR phosphorylation at Ser220, which is critical for the anti-apoptotic effects hydrocortisone on hepatic ischemia-reperfusion injury.
a significant protein-protein interaction between GR and CHOP (show DDIT3 ELISA Kits), (GR-CHOP (show DDIT3 ELISA Kits) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (show PPARA ELISA Kits) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (show CDK5R1 ELISA Kits); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (show CDK5R1 ELISA Kits)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (show HSP90 ELISA Kits)-p23 (show CDK5R1 ELISA Kits) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (show NR1D1 ELISA Kits) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha and HSP90beta (show HSP90AB1 ELISA Kits), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (show PRKAA1 ELISA Kits) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (show PPARA ELISA Kits) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
GR signaling decreases NRF2 (show NFE2L2 ELISA Kits) transcriptional activation through reducing the NRF2 (show NFE2L2 ELISA Kits)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (show NFE2L2 ELISA Kits)-mediated cytoprotection from oxidative stress.
GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (show PPARA ELISA Kits)-FGF21 (show FGF21 ELISA Kits) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 ELISA Kits) complex that favor FKBP51 (show FKBP5 ELISA Kits) repression over FKBP52 (show FKBP4 ELISA Kits) potentiation.
Results provide evidence for an association between the NR3C1-rs41423247 SNP and depression: C minor allele of rs41423247 increased depressive symptoms during early abstinence of women with crack cocaine addiction, but it did not have effects over detoxification treatment. A slight effect of CC genotype was shown at late abstinence phase. C allele of this SNP was associated to an increased number of rehospitalizations.
There was no significant interaction between NR3C1 and stressful life events with respect to alcohol use/misuse.
Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 (show SFRS9 ELISA Kits) and SRSF3 (show SRSF3 ELISA Kits) in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.
Association between suicide and altered NR3C1 gene expression in the prefrontal cortex.
Results identified three novel heterozygous missense NR3C1 mutations causing glucocorticoid resistance in patients with adrenal incidentalomas without Cushing's syndrome. p.R477S and p.Y478C are located in the DNA binding domain (DBD) of the glucocorticoid receptor (GR) while p.L67P is located in the ligand binding domain of GR.
Data show that the 3' UTR (show UTS2R ELISA Kits) of glucocorticoid receptor beta (GRbeta) is regulated by miR144.
Except for a slightly higher risk of bronchopulmonary dysplasia (BPD) in carriers of the GRBclI variant, the glucocorticoid receptor gene polymorphisms BclI, N363S, and R23K did not affect neonatal outcome parameters in this large multicenter cohort of Very-Low-Birth-Weight preterm infants.
A woman with glucocorticoid resistance and her mother had a novel p.Arg477Cys (c.1429C>T) mutation in exon 4 of NR3C1, in the 2dzinc finger of the DNA-binding domain. Its 'in silico' functional effect was assessed using pathogenicity prediction software, being characterized as pathogenic. An unrelated patient had a novel p.His588Leufs*5 (c.1762_1763insTTAC) mutation, in exon 6, in the ligand binding domain.
NR3C1 as an important gene of the hypothalamic-pituitary-adrenal axis seems to be particularly relevant for the pathophysiology of ADHD combined with comorbid CD.
These results indicate that myostatin (show MSTN ELISA Kits) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 ELISA Kits) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 ELISA Kits) and specificity protein 1 (Sp1 (show SP1 ELISA Kits)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 ELISA Kits) and PTGS2 (show PTGS2 ELISA Kits), and decreased the expression of SOD2 (show SOD2 ELISA Kits), GPX3 (show GPX3 ELISA Kits), DAB2 (show DAB2 ELISA Kits), and NR3C1. TNF (show TNF ELISA Kits) and IL6 (show IL6 ELISA Kits) levels were also decreased while those of NAMPT (show NAMPT ELISA Kits) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 ELISA Kits) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS ELISA Kits), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma