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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||6 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||11 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Western Blotting (WB)||56 Antibodies|
|Antigen||Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) Antibodies|
|Epitope||AA 133-165, C-Term Alternatives|
|Conjugate||This GADD45A antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-GADD45A AntibodyTarget Details GADD45A Application Details Handling References for anti-GADD45A Antibody (ABIN650724) Images
|Specificity||This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136~165 amino acids from the C-terminal region of human GADD45A.|
|Predicted Reactivity||Cow (Bovine),Hamster,Mouse (Murine),Rat (Rattus)|
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Immunogen||This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 AA from the C-terminal region of human GADD45A.|
Target Details GADD45AProduct Details anti-GADD45A Antibody Application Details Handling References for anti-GADD45A Antibody (ABIN650724) Images back to top
|Alternative Name||GADD45A (GADD45A Antibody Abstract)|
GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
Synonyms: Growth arrest and DNA-damage-inducible protein GADD45 alpha, DNA-damage-inducible transcript 1, DDIT-1, GADD45A, DDIT1, GADD45
|Molecular Weight||18205 DA|
|Research Area||Stem Cells, Protein Modifications|
|Pathways||p53 Signaling, Cell Division Cycle|
Application DetailsProduct Details anti-GADD45A Antibody Target Details GADD45A Handling References for anti-GADD45A Antibody (ABIN650724) Images back to top
|Application Notes||WB = 1:1000, FACS = 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-GADD45A Antibody Target Details GADD45A Application Details References for anti-GADD45A Antibody (ABIN650724) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.|
|Expiry Date||6 months|
References for anti-GADD45A Antibody (ABIN650724)Product Details anti-GADD45A Antibody Target Details GADD45A Application Details Handling Images back to top
|Product cited in:||
Wu, Boonmars, Nagano et al.: "Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma." in: International journal of cancer. Journal international du cancer, 2015 (PubMed).
Li, Morales, Hwang et al.: "DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis." in: The Journal of biological chemistry, Vol. 283, Issue 31, pp. 21394-403, 2008 (PubMed).
Al-Romaih, Sadikovic, Yoshimoto et al.: "Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 5, pp. 471-80, 2008 (PubMed).
Zhu, Ren, Korchin et al.: "Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha." in: Cancer research, Vol. 68, Issue 8, pp. 2895-903, 2008 (PubMed).
Kearsey, Coates, Prescott et al.: "Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1." in: Oncogene, Vol. 11, Issue 9, pp. 1675-83, 1995 (PubMed).
ImagesProduct Details anti-GADD45A Antibody Target Details GADD45A Application Details Handling References for anti-GADD45A Antibody (ABIN650724) back to top