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Browse our p300 Proteins (EP300)

Full name:
E1A Binding Protein P300 Proteins (EP300)
On www.antibodies-online.com are 9 E1A Binding Protein P300 (EP300) Proteins from 5 different suppliers available. Additionally we are shipping p300 Antibodies (270) and p300 Kits (16) and many more products for this protein. A total of 311 p300 products are currently listed.
Synonyms:
A430090G16, A730011L11, KAT3B, p300, p300 HAT, RSTS2
list all proteins Gene Name GeneID UniProt
EP300 2033 Q09472
EP300 328572  
EP300 170915  

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p300 Proteins (EP300) by Origin

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Top referenced p300 Proteins

  1. Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219 : Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016 (PubMed)

More Proteins for p300 Interaction Partners

Human E1A Binding Protein P300 (EP300) interaction partners

  1. 2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.

  2. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Proteins)/EGR1 (show EGR1 Proteins)/SIRT1 (show SIRT1 Proteins) signaling, and AKT (show AKT1 Proteins) and p300 negatively regulate this process via Bim (show BCL2L11 Proteins) upregulation.

  3. A potential mechanism for the role of Sirt1 (show SIRT1 Proteins) in lung fibrosis was through regulating the expression of p300. Thus, we characterized Sirt1 (show SIRT1 Proteins) as an important regulator of lung fibrosis and provides a proof of principle for activation or overexpression of Sirt1 (show SIRT1 Proteins) as a potential novel therapeutic strategy for IPF.

  4. Results suggest that increase in nuclear expression of p300, as well as the presence of cytoplasmic but loss of nuclear expression of p300/CBP-associated factor (PCAF (show KAT2B Proteins)), could play an important role in the development and progression of cutaneous squamous cell carcinomas (SCC (show CYP11A1 Proteins)).

  5. Acetylation of lysine 109 modulates PXR (show NR1I2 Proteins) DNA binding and transcriptional activity; PXR (show NR1I2 Proteins) acetylation status and transcriptional activity are modulated by E1A binding protein (p300) and SIRT1 (show SIRT1 Proteins).

  6. We show that a DUX4 minigene, bearing only the homeodomains and C-terminus, is transcriptionally functional and cytotoxic, and that overexpression of a nuclear targeted C-terminus impairs the ability of WT DUX4 to interact with p300 and to regulate target genes.

  7. These results suggest that OCT (show Plxna2 Proteins) attenuates SGC (show SGCB Proteins)-7901 cell proliferation by enhancing P300-HAT activity through the interaction of ZAC (show PLAGL1 Proteins) and P300, causing a reduction in pS10-H3 and an increase in acK14-H3. These findings provide insight for future research on OCT (show Plxna2 Proteins) and further demonstrate the potential of OCT (show Plxna2 Proteins) to be used as a therapeutic agent for gastric cancer

  8. C646 treatment attenuated ETV1 protein expression and inactivated KIT-dependent pathways. Taken together, the present study suggests that CBP/p300 may serve as novel antineoplastic targets and that use of the selective HAT inhibitor C646 is a promising antitumor strategy for Gastrointestinal stromal tumors.

  9. High p300 expression is associated with migratory and invasive behavior in pancreatic cancer.

  10. Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ]

Mouse (Murine) E1A Binding Protein P300 (EP300) interaction partners

  1. 2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.

  2. work shows that helenalin acetate inhibits C/EBPbeta (show CEBPB Proteins) by binding to the N-terminal part of C/EBPbeta (show CEBPB Proteins), thereby disrupting the cooperation of C/EBPbeta (show CEBPB Proteins) with the co-activator p300 (show NOTCH1 Proteins).

  3. STAT6 (show STAT6 Proteins) mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 (show STAT6 Proteins) mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.

  4. Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.

  5. Hdac3 (show HDAC3 Proteins) cooperates with p300 (show NOTCH1 Proteins) to prime and maintain oligodendrocyte identity

  6. p300 (show NOTCH1 Proteins) histone acetyltransferase activity is critical for Wnt (show WNT2 Proteins)-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate.

  7. Data indicate that glucose-induced endothelial to mesenchymal transition in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR (show MLXIP Proteins)-200b and p300 (show NOTCH1 Proteins).

  8. This study demonstrated that p300 (show NOTCH1 Proteins) increase in skeletal muscle in muscle atrophy.

  9. This study demonstrates that p300 (show NOTCH1 Proteins) mediates histone acetylation of PS1 (show PSEN1 Proteins) and BACE1 (show BACE Proteins) in a cellular model of Alzheimer's disease.

  10. p300 (show NOTCH1 Proteins) regulates a number of critical signaling pathways that control liver functions.

p300 (EP300) Protein Profile

Protein Summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Alternative names and synonyms associated with p300 (EP300)

  • E1A binding protein p300 (EP300)
  • E1A-associated protein p300 (ep300)
  • E1A binding protein p300 (ep300)
  • E1A binding protein p300 (Ep300)
  • A430090G16 protein
  • A730011L11 protein
  • KAT3B protein
  • p300 protein
  • p300 HAT protein
  • RSTS2 protein

Protein level used designations for EP300

histone acetyltransferase p300 , histone acetyltransferase , E1A binding protein p300 , histone acetyltransferase p300-like , E1A-associated protein p300 , E1A-binding protein, 300kD , p300 HAT

GENE ID SPECIES
100055626 Equus caballus
458862 Pan troglodytes
706258 Macaca mulatta
446056 Takifugu rubripes
100028102 Monodelphis domestica
100455260 Pongo abelii
100468694 Ailuropoda melanoleuca
100543704 Meleagris gallopavo
100566746 Anolis carolinensis
2033 Homo sapiens
328572 Mus musculus
418000 Gallus gallus
100684945 Canis lupus familiaris
100156226 Sus scrofa
170915 Rattus norvegicus
100734820 Cavia porcellus
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