Browse our p300 Proteins (EP300)

Full name:
E1A Binding Protein P300 Proteins (EP300)
On are 9 E1A Binding Protein P300 (EP300) Proteins from 5 different suppliers available. Additionally we are shipping p300 Antibodies (269) and p300 Kits (16) and many more products for this protein. A total of 310 p300 products are currently listed.
A430090G16, A730011L11, KAT3B, p300, p300 HAT, RSTS2
list all proteins Gene Name GeneID UniProt
EP300 2033 Q09472
EP300 328572  
EP300 170915  

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p300 Proteins (EP300) by Origin

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Top referenced p300 Proteins

  1. Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219 : Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016 (PubMed)

More Proteins for p300 Interaction Partners

Human E1A Binding Protein P300 (EP300) interaction partners

  1. Although TP53 (show TP53 Proteins) and BAX (show BAX Proteins) immunoreactivity levels were associated with some clinicopathological parameters of the patients, the expression of EP300, TP53 (show TP53 Proteins) and BAX (show BAX Proteins) did not reveal any prognostic significance in ccRCC

  2. 5-FU promotes global histone de-acetylation by enhancing the degradation of p300/CBP (show CREBBP Proteins) in colorectal neoplasms.

  3. ELF3 interacts directly with the HMG domain of Sox9. Importantly, overexpression of ELF3 significantly decreased Sox9/CBP-dependent HAT activity.

  4. CTPB promoted the survival and neurite growth of the SH-SY5Y cells, and also protected these cells from cell death induced by the neurotoxin 6-hydroxydopamine. This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300/CBP HAT activation has neurotrophic effects in a cellular model of Parkinson's Disease.

  5. c-Jun (show JUN Proteins) and p300 are novel interacting partners of AEG-1 (show MTDH Proteins) in gliomas.

  6. 2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.

  7. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 Proteins)/EGR1 (show EGR1 Proteins)/SIRT1 (show SIRT1 Proteins) signaling, and AKT (show AKT1 Proteins) and p300 negatively regulate this process via Bim (show BCL2L11 Proteins) upregulation.

  8. A potential mechanism for the role of Sirt1 (show SIRT1 Proteins) in lung fibrosis was through regulating the expression of p300. Thus, we characterized Sirt1 (show SIRT1 Proteins) as an important regulator of lung fibrosis and provides a proof of principle for activation or overexpression of Sirt1 (show SIRT1 Proteins) as a potential novel therapeutic strategy for IPF.

  9. Results suggest that increase in nuclear expression of p300, as well as the presence of cytoplasmic but loss of nuclear expression of p300/CBP-associated factor (PCAF (show KAT2B Proteins)), could play an important role in the development and progression of cutaneous squamous cell carcinomas (SCC (show CYP11A1 Proteins)).

  10. Acetylation of lysine 109 modulates PXR (show NR1I2 Proteins) DNA binding and transcriptional activity; PXR (show NR1I2 Proteins) acetylation status and transcriptional activity are modulated by E1A binding protein (p300) and SIRT1 (show SIRT1 Proteins).

Mouse (Murine) E1A Binding Protein P300 (EP300) interaction partners

  1. Data, including data from studies in cells from knockout mice, suggest that Prmt1 (show PRMT1 Proteins) activity was necessary for c-Myc (show MYC Proteins) binding to acetyltransferase p300 (show NOTCH1 Proteins) in myeloid cells; Prmt1 (show PRMT1 Proteins) inhibition decreases p300 (show NOTCH1 Proteins) recruitment to c-Myc (show MYC Proteins) target promoters and increased Hdac1 (show HDAC1 Proteins) recruitment. [Prmt1 (show PRMT1 Proteins), protein arginine N-methyltransferase 1 (show PRMT1 Proteins); c-Myc (show MYC Proteins) = Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins); Hdac1 (show HDAC1 Proteins) = histone deacetylase 1 (show HDAC1 Proteins)]

  2. In line with the acetyltransferase activity of p300 (show NOTCH1 Proteins), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Proteins) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Proteins) to its gene

  3. ARX positively regulates Wnt (show WNT2 Proteins)/ beta-catenin (show CTNNB1 Proteins) signaling and the C-terminal domain of ARX interacts with the armadillo (show PKP1 Proteins) repeats in beta-catenin (show CTNNB1 Proteins) to promote Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling. In addition, we found BCL9 (show BCL9 Proteins) and P300 (show NOTCH1 Proteins) also interact with ARX to modulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. 2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.

  5. work shows that helenalin acetate inhibits C/EBPbeta (show CEBPB Proteins) by binding to the N-terminal part of C/EBPbeta (show CEBPB Proteins), thereby disrupting the cooperation of C/EBPbeta (show CEBPB Proteins) with the co-activator p300 (show NOTCH1 Proteins).

  6. STAT6 (show STAT6 Proteins) mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 (show STAT6 Proteins) mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.

  7. Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.

  8. Hdac3 (show HDAC3 Proteins) cooperates with p300 (show NOTCH1 Proteins) to prime and maintain oligodendrocyte identity

  9. p300 (show NOTCH1 Proteins) histone acetyltransferase activity is critical for Wnt (show WNT2 Proteins)-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate.

  10. Data indicate that glucose-induced endothelial to mesenchymal transition in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR (show MLXIP Proteins)-200b and p300 (show NOTCH1 Proteins).

p300 (EP300) Protein Profile

Protein Summary

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Alternative names and synonyms associated with p300 (EP300)

  • E1A binding protein p300 (EP300)
  • E1A-associated protein p300 (ep300)
  • E1A binding protein p300 (ep300)
  • E1A binding protein p300 (Ep300)
  • A430090G16 protein
  • A730011L11 protein
  • KAT3B protein
  • p300 protein
  • p300 HAT protein
  • RSTS2 protein

Protein level used designations for EP300

histone acetyltransferase p300 , histone acetyltransferase , E1A binding protein p300 , histone acetyltransferase p300-like , E1A-associated protein p300 , E1A-binding protein, 300kD , p300 HAT

100055626 Equus caballus
458862 Pan troglodytes
706258 Macaca mulatta
446056 Takifugu rubripes
100028102 Monodelphis domestica
100455260 Pongo abelii
100468694 Ailuropoda melanoleuca
100543704 Meleagris gallopavo
100566746 Anolis carolinensis
2033 Homo sapiens
328572 Mus musculus
418000 Gallus gallus
100684945 Canis lupus familiaris
100156226 Sus scrofa
170915 Rattus norvegicus
100734820 Cavia porcellus
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