Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219
Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016
Pre-eclampsia occurs in 12/52 mothers of EP300 mutated individuals versus in 2/59 mothers of CREBBP (show CREBBP Proteins) mutated individuals, making pregnancy with an EP300 mutated fetus the strongest known predictor for pre-eclampsia
EP300-ZNF384 (show ZNF384 Proteins) mediates GATA3 (show GATA3 Proteins) gene expression and may be involved in the acquisition of the HSC (show FUT1 Proteins) gene expression signature and characteristic immunophenotype in B-cell precursor acute lymphoblastic leukemia cells.
Estrogen receptor (show ESR1 Proteins) recruits steroid receptor coactivator (show SRA1 Proteins)-3 primary coactivator and secondary coactivators, p300/CBP (show CREBBP Proteins) and CARM1 (show CARM1 Proteins) to regulate genetic transcription.
the depleted beta-Arrestin1 (show ARRB1 Proteins) reduced the interaction of P300 with Sp1 (show PSG1 Proteins), thus to reduce Sp1 (show PSG1 Proteins) binding to hTERT promoter, downregulate hTERT transcription, decrease telomerase activity, shorten telomere length, and promote Reh (show CES1 Proteins) cell senescence.
Authors report that p300 and CBP (show CREBBP Proteins) acetylate Mastermind-like 1 (Maml1 (show MAML1 Proteins)) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (show NOTCH1 Proteins) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
Genome-wide gene expression profiling identified a network of VEGF (show VEGFA Proteins)-responsive and ERG (show ERG Proteins)-dependent genes.
our findings identify the TXN (show TXN Proteins)-FOXO1 (show FOXO1 Proteins)-p300 circuit as the sensor and effector of oxidative stress in DLBCL cells
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Proteins) and HDAC1-HDAC2 (show HDAC1 Proteins) has been described.
Although TP53 (show TP53 Proteins) and BAX (show BAX Proteins) immunoreactivity levels were associated with some clinicopathological parameters of the patients, the expression of EP300, TP53 (show TP53 Proteins) and BAX (show BAX Proteins) did not reveal any prognostic significance in ccRCC
5-FU promotes global histone de-acetylation by enhancing the degradation of p300/CBP (show CREBBP Proteins) in colorectal neoplasms.
Loss of p300 (show NOTCH1 Proteins) expression is associated with leukemogenesis.
UTX (show KDM6A Proteins)-MLL4-p300 (show NOTCH1 Proteins) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (show PRMT1 Proteins) activity was necessary for c-Myc (show MYC Proteins) binding to acetyltransferase p300 (show NOTCH1 Proteins) in myeloid cells; Prmt1 (show PRMT1 Proteins) inhibition decreases p300 (show NOTCH1 Proteins) recruitment to c-Myc (show MYC Proteins) target promoters and increased Hdac1 (show HDAC1 Proteins) recruitment. [Prmt1 (show PRMT1 Proteins), protein arginine N-methyltransferase 1 (show PRMT1 Proteins); c-Myc (show MYC Proteins) = Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins); Hdac1 (show HDAC1 Proteins) = histone deacetylase 1 (show HDAC1 Proteins)]
In line with the acetyltransferase activity of p300 (show NOTCH1 Proteins), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Proteins) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Proteins) to its gene
ARX positively regulates Wnt (show WNT2 Proteins)/ beta-catenin (show CTNNB1 Proteins) signaling and the C-terminal domain of ARX interacts with the armadillo (show PKP1 Proteins) repeats in beta-catenin (show CTNNB1 Proteins) to promote Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling. In addition, we found BCL9 (show BCL9 Proteins) and P300 (show NOTCH1 Proteins) also interact with ARX to modulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 (show HMGB1 Proteins) release, at least in part, by direct molecular inhibition of p300 HAT activity.
work shows that helenalin acetate inhibits C/EBPbeta (show CEBPB Proteins) by binding to the N-terminal part of C/EBPbeta (show CEBPB Proteins), thereby disrupting the cooperation of C/EBPbeta (show CEBPB Proteins) with the co-activator p300 (show NOTCH1 Proteins).
STAT6 (show STAT6 Proteins) mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 (show STAT6 Proteins) mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.
Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT