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Human p300 Protein expressed in Sf-9 Cells - ABIN2720219
Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016
High p300 expression is associated with migratory and invasive behavior in pancreatic cancer.
Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ]
p300 protein and mRNA were not expressed in normal brain, but were expressed in pediatric astrocytoma in levels decreasing with tumor grade.
By characterizing six novel EP300-mutated Rubinstein-Taybi patients patients, this study provides further insights into the EP300-specific clinical presentation and expands the mutational repertoire including the first case of a whole gene deletion.
The axis EP300-->E-cadherin (show CDH1 Proteins), which is controlled by the miR (show MLXIP Proteins)-106b~25 cluster, regulates paclitaxel resistance in breast cancer cells by apoptosis evasion independent of ABC (show ABCB6 Proteins) transporters.
Sox4 was also able to promote b-catenin-mediated transcription of the Slug (show SNAI2 Proteins) gene through formation of transcriptional complexes with b-catenin and p300, independent of TCF4 (show TCF4 Proteins) status
RORgammat is acetylated, and this acetylation is reciprocally regulated by the histone acetyltransferase p300 and the histone deacetylase HDAC1 (show HDAC1 Proteins).
levels of p300 protein are temporally maintained in ligand-enhanced skeletal myocyte development. this maintenance of p300 protein is observed at the stage of myoblast differentiation, which coincides with an increase in Akt (show AKT1 Proteins) phosphorylation.
PIAS1 (show PIAS1 Proteins) enhances p300 recruitment to c-Myb (show MYB Proteins)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 (show PIAS1 Proteins) enhances further its coactivation
coactivator p300 mediates cytokine-induced hiNOS transactivation by forming a distant DNA loop between its enhancer and core promoter region
STAT6 (show STAT6 Proteins) mediates the CT-induced TIM4 (show TIMD4 Proteins) expression in DCs. In conclusion, p300 (show NOTCH1 Proteins) and STAT6 (show STAT6 Proteins) mediate the microbial product CT-induced TIM4 (show TIMD4 Proteins) expression in DCs.
Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.
Hdac3 (show HDAC3 Proteins) cooperates with p300 (show NOTCH1 Proteins) to prime and maintain oligodendrocyte identity
p300 (show NOTCH1 Proteins) histone acetyltransferase activity is critical for Wnt (show WNT2 Proteins)-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate.
Data indicate that glucose-induced endothelial to mesenchymal transition in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR (show MLXIP Proteins)-200b and p300 (show NOTCH1 Proteins).
This study demonstrated that p300 (show NOTCH1 Proteins) increase in skeletal muscle in muscle atrophy.
This study demonstrates that p300 (show NOTCH1 Proteins) mediates histone acetylation of PS1 (show PSEN1 Proteins) and BACE1 (show BACE Proteins) in a cellular model of Alzheimer's disease.
p300 (show NOTCH1 Proteins) regulates a number of critical signaling pathways that control liver functions.
p300 (show NOTCH1 Proteins) conditional knockout in Treg cells leads to minimal changes in Treg functions.
on Bcl6 (show BCL6 Proteins), p300 (show NOTCH1 Proteins) functioned as a repressor and inhibited in conjunction with STAT5 (show STAT5A Proteins) or BCL6 (show BCL6 Proteins).
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT