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The bromodomain and extraterminal domain (BET) family consists of BRDT (show BRDT Proteins), BRD2 (show BRD2 Proteins), BRD3 (show BRD3 Proteins), and BRD4 (show BRD4 Proteins), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The identification of RNF43 (show RNF43 Proteins) mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease
LRP1B (show LRP1B Proteins), BRD2 (show BRD2 Proteins) and CACNA1D (show CACNA1D Proteins) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 (show BRD2 Proteins) and BRD4 (show BRD4 Proteins) in maintaining oncogenic IKK (show CHUK Proteins) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 (show BRD2 Proteins) and Brd4 (show BRD4 Proteins), may play a key role in the regulation of Nrf2 (show GABPA Proteins)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 (show BRD2 Proteins) is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2 (show BRD2 Proteins)/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
The SNP alleles in BRD2 (show BRD2 Proteins), Cx-36 (show GJD2 Proteins), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'
BRD2 (show BRD2 Proteins), BRD3 (show BRD3 Proteins), and BRD4 (show BRD4 Proteins) interact with gammaretroviral INs (show INS Proteins) and serve as cofactors for murine leukemia virus integration.
the in vivo bioactivities of FSH (show BRD2 Proteins) glycoforms in Fshb (show FSHB Proteins) null mice using a pharmacological rescue approach, was investigated.
These mice showed an increase in FSH (show BRD2 Proteins) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (show LEP Proteins)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
GnRH (show GNRH1 Proteins) stimulated the secretion of the VGF (show VGF Proteins)-derived peptide NERP1 (show VGF Proteins). NERP1 (show VGF Proteins) caused a concentration-dependent decrease in Fshb (show FSHB Proteins) gene induction.
the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (show LHB Proteins)), follicle stimulating hormone beta (Fshb (show FSHB Proteins)), and intracellular adhesion molecule (show NCAM1 Proteins)-5 (Icam5 (show ICAM5 Proteins)) in females but only decreased expression of Icam5 (show ICAM5 Proteins) in males.
GnRH (show GNRH1 Proteins) stimulation of Fshb (show FSHB Proteins) expression is dependent on miR (show MLXIP Proteins)-132/212 and involves a SIRT1 (show SIRT1 Proteins)-FOXO1 (show FOXO1 Proteins) pathway.
results suggest that FOXO1 (show FOXO1 Proteins) binding to the proximal Fshb (show FSHB Proteins) promoter as well as FOXO1 (show FOXO1 Proteins) interaction with SMAD3 (show SMAD3 Proteins)/4 proteins may result in decreased activin induction of Fshb (show FSHB Proteins) in gonadotropes
SCGB3A2 (show SCGB3A2 Proteins) regulates FSH (show BRD2 Proteins)/LH production in the anterior pituitary lobe.
Data suggest that the BMP2 (show BMP2 Proteins)-like Activin A (show INHBA Proteins)/BMP2 (show BMP2 Proteins) chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A (show INHBA Proteins) signaling.
Two regions of the proximal Fshb (show FSHB Proteins) promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 (show FOXO1 Proteins) suppression of GnRH (show GNRH1 Proteins)-induced Fshb (show FSHB Proteins) transcription.
Report changes in hormone secretion and response of isolated ovarian tissue from transgenic animals to FSH (show BRD2 Proteins) and ghrelin (show GHRL Proteins).
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, follicle-stimulating hormone beta subunit
, follitropin beta chain
, follitropin subunit beta