SPANX Family, Member B1 (SPANXB1) (Middle Region) Peptide
SPANXB1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SPANXB1 products
- SPANXB1 (SPANX Family, Member B1 (SPANXB1))
- Protein Region
- Middle Region
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MPETPTGDSD PQPAPKKMKT SESSTILVVR YRRNVKRTSP EELVNDHARE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPANXB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SPANXB1 (SPANX Family, Member B1 (SPANXB1))
- Synonyms
- B1 Peptide, CT11.2 Peptide, SPANX-B Peptide, SPANXB Peptide, SPANX family member B1 Peptide, SPANXB1 Peptide
- Background
-
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.
Alias Symbols: B1, CT11.2, SPANX-B, SPANXB
Protein Size: 103 - Molecular Weight
- 12 kDa
- Gene ID
- 728695
- NCBI Accession
- NM_032461, NP_115850
- UniProt
- Q9NS25
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