Growth Factor Independent 1 (GFI1) (N-Term) Peptide
GFI1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GFI1 products
- GFI1 (Growth Factor Independent 1 (GFI1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KKAHSYHQPR SPGPDYSLRL ENVPAPSRAD STSNAGGAKA EPRDRLSPES
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GFI1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GFI1 (Growth Factor Independent 1 (GFI1))
- Synonyms
- AW495828 Peptide, Gfi-1 Peptide, Pal-1 Peptide, Pal1 Peptide, GFI1 Peptide, GFI-1 Peptide, GFI1A Peptide, SCN2 Peptide, ZNF163 Peptide, growth factor independent 1 Peptide, growth factor independent 1 transcriptional repressor Peptide, Gfi1 Peptide, GFI1 Peptide
- Background
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This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Alias Symbols: GFI1,ZNF163,
Protein Size: 422 - Gene ID
- 2672
- NCBI Accession
- XP_005270806
- UniProt
- Q99684
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