Ras-Related GTP Binding A (RRAGA) (C-Term) Peptide
RRAGA
Reactivity: Human
Host: Synthetic
WB, BP
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- Target See all RRAGA products
- RRAGA (Ras-Related GTP Binding A (RRAGA))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB), Blocking Peptide (BP)
- Sequence
- CKEQRDVHRF EKISNIIKQF KLSCSKLAAS FQSMEVRNSN FAAFIDIFTS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RRAGA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RRAGA (Ras-Related GTP Binding A (RRAGA))
- Synonyms
- FIP-1 Peptide, FIP1 Peptide, RAGA Peptide, 1300010C19Rik Peptide, AI255374 Peptide, Raga Peptide, Ras related GTP binding A Peptide, Ras-related GTP binding A Peptide, RRAGA Peptide, Rraga Peptide
- Background
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RRAGA is a guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. It may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Also it may alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Alias Symbols: RRAGA,
Protein Size: 313 - Gene ID
- 10670
- NCBI Accession
- NP_006561
- UniProt
- Q7L523
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