AKT Interacting Protein (AKTIP) (Middle Region) Peptide
AKTIP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all AKTIP products
- AKTIP (AKT Interacting Protein (AKTIP))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-AKTIP antibody (Catalog #: ARP56199_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- AKTIP (AKT Interacting Protein (AKTIP))
- Synonyms
- FT1 Peptide, FTS Peptide, cb798 Peptide, fts Peptide, zgc:77699 Peptide, fts-A Peptide, aktip Peptide, fts-B Peptide, MGC133931 Peptide, AL023020 Peptide, Fif Peptide, Ft Peptide, Ft1 Peptide, Fts Peptide, AKT interacting protein Peptide, akt interacting protein Peptide, AKT interacting protein L homeolog Peptide, AKT interacting protein S homeolog Peptide, thymoma viral proto-oncogene 1 interacting protein Peptide, AKTIP Peptide, aktip Peptide, aktip.L Peptide, aktip.S Peptide, Aktip Peptide
- Background
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AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Alias Symbols: FT1, FTS
Protein Interaction Partner: AKT1,ASS1,C10orf2,CTBP2,EXOC7,GTF3C1,HOOK2,IMMT,KIAA1377,PDPK1,POLA2,RPA1,UTP14A,AKT1,ASS1,C10orf2,CTBP2,DCTN1,EXOC7,GTF3C1,HDLBP,HOOK1,HOOK2,IARS,IMMT,KIAA1377,PDS5A,POLA2,RPA1,TIMM50,UTP14A
Protein Size: 292 - Molecular Weight
- 33 kDa
- Gene ID
- 64400
- NCBI Accession
- NM_001012398, NP_001012398
- UniProt
- Q9H8T0
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