Chromosome 6 Open Reading Frame 150 (C6orf150) (C-Term) Peptide
C6orf150
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all C6orf150 products
- C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PASTQEGLRI QNWLSAKVRK QLRLKPFYLV PKHAKEGNGF QEETWRLSFS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CGAS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
- Synonyms
- C6orf150 Peptide, cGAS Peptide, h-cGAS Peptide, Mab-21 domain containing 1 Peptide, cyclic GMP-AMP synthase Peptide, MB21D1 Peptide, CGAS Peptide
- Background
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CGAS is a Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. It has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
Alias Symbols: MB21D1,C6orf150,
Protein Size: 522 - Molecular Weight
- 59 kDa
- Gene ID
- 115004
- NCBI Accession
- NP_612450
- UniProt
- Q8N884
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