Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B) Peptide
CDC25B
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all CDC25B products
- CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CDC25B antibody (Catalog #: ARP41336_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))
- Background
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CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Protein Interaction Partner: AR,AURKA,BRSK1,BRSK2,CDK1,CHEK1,CREBBP,CSNK2A1,CSNK2B,ESR1,FHL3,KAT2B,MAPK14,MAPK14,MAPKAPK2,MELK,SFN,YWHAB,YWHAE,YWHAH,YWHAQ,YWHAZ,YWHAZ,AR,CDK2,CHEK1,CSNK2A1,ESR1,FBXW11,KAT2B,KRT31,KRT35,KRT85,MAPK14,MELK,PGR,PHB2,YWHAB,YWHAB,YWHAE,YWHAE,YWHAH,YWHAQ,YWHAZ
Protein Size: 580 - Molecular Weight
- 65 kDa
- Gene ID
- 994
- NCBI Accession
- NM_021873, NP_068659
- UniProt
- P30305
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