Complement Factor I (CFI) (N-Term) Peptide
CFI
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Complement Factor I (CFI) products
- Complement Factor I (CFI)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- WSMREANVAC LDLGFQQGAD TQRRFKLSDL SINSTECLHV HCRGLETSLA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CFI Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Complement Factor I (CFI)
- Synonyms
- cfi Peptide, MGC53615 Peptide, Cfi Peptide, factor I Peptide, IF Peptide, gb:ai721528 Peptide, ahus3 Peptide, c3b-ina Peptide, c3bc4bi Peptide, c3bina Peptide, kaf Peptide, CFI Peptide, AHUS3 Peptide, C3BINA Peptide, C3b-INA Peptide, FI Peptide, KAF Peptide, complement factor I S homeolog Peptide, complement factor I L homeolog Peptide, complement factor I Peptide, complement component factor i Peptide, cfi.S Peptide, cfi.L Peptide, CFI Peptide, cfi Peptide, Cfi Peptide
- Background
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This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.
Alias Symbols: AHUS3, C3BINA, C3b-INA, FI, IF, KAF
Protein Interaction Partner: C3,CFH,C3
Protein Size: 583 - Molecular Weight
- 64 kDa
- Gene ID
- 3426
- NCBI Accession
- NM_000204, NP_000195
- UniProt
- P05156
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