Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (N-Term) Peptide
ERCC2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ERCC2 products
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- Protein Region
- N-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ERCC2 antibody (Catalog #: P100701_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- Synonyms
- COFS2 Peptide, EM9 Peptide, TTD Peptide, XPD Peptide, AA407812 Peptide, AU020867 Peptide, AW240756 Peptide, CXPD Peptide, Ercc-2 Peptide, MGC89573 Peptide, CG9433 Peptide, DhR3 Peptide, DhXPD Peptide, DmXPD Peptide, Dmel\\CG9433 Peptide, ERCC2 Peptide, XPD/ERCC2 Peptide, l(2)SH2 2137 Peptide, l(2)SH2137 Peptide, xpd Peptide, zgc:56365 Peptide, ERCC excision repair 2, TFIIH core complex helicase subunit Peptide, excision repair cross-complementing rodent repair deficiency, complementation group 2 Peptide, excision repair cross-complementation group 2 Peptide, Xeroderma pigmentosum D Peptide, ERCC2 Peptide, Ercc2 Peptide, ercc2 Peptide, Xpd Peptide
- Background
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The nucleotide excision repair pathway is a mechanism to repair damage to DNA. ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. This protein has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Protein Interaction Partner: CDK1,CDK7,ERCC2,ERCC3,ERCC5,GTF2H1,GTF2H2,RAD51,RAD52,ERCC3,ERCC5,GTF2H1,GTF2H2,HERC5,ISG15,TP53,TRIM25
Protein Size: 760 - Molecular Weight
- 87 kDa
- Gene ID
- 2068
- NCBI Accession
- NM_000400, NP_000391
- UniProt
- P18074
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