TNF Receptor Superfamily, Member 6 (FAS) (N-Term) Peptide
FAS
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FAS products
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FAS Antibody(ARP59115_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Synonyms
- ALPS1A Peptide, APO-1 Peptide, APT1 Peptide, CD95 Peptide, FAS1 Peptide, FASTM Peptide, TNFRSF6 Peptide, AI196731 Peptide, APO1 Peptide, TNFR6 Peptide, Tnfrsf6 Peptide, lpr Peptide, Fas cell surface death receptor Peptide, Fas (TNF receptor superfamily member 6) Peptide, FAS Peptide, Fas Peptide, fas Peptide
- Background
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FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Symbols: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Protein Interaction Partner: CTNNB1,KAT5,RUVBL2,TP63,SUMO1,ANK3,APAF1,BTK,C14orf1,C1orf103,CALM1,CASP8,CASP8AP2,CD47,CRMP1,DAXX,EEF1A1,EGFR,EZR,FADD,FAF1,FAIM2,FAS,FASLG,FBF1,FEM1B,FYN,HIPK3,LCK,MET,PDCD6,PRKCA,PTPN13,PTPN6,RAP1A,RIPK1,SUMO1,TNFSF13,TRADD,UBA7,UBE2I,ARHGDIA,BID,BRE,C
Protein Size: 335 - Molecular Weight
- 36 kDa
- Gene ID
- 355
- NCBI Accession
- NM_000043, NP_000034
- UniProt
- P25445
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