Osteoactivin (GPNMB) Peptide
GPNMB
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all Osteoactivin (GPNMB) products
- Osteoactivin (GPNMB)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GPNMB antibody (Catalog #: ARP44499_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Osteoactivin (GPNMB)
- Synonyms
- HGFIN Peptide, NMB Peptide, DC-HIL Peptide, Dchil Peptide, ipd Peptide, glycoprotein nmb Peptide, glycoprotein (transmembrane) nmb Peptide, glycoprotein nmb L homeolog Peptide, Gpnmb Peptide, GPNMB Peptide, gpnmb.L Peptide
- Background
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GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential.The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HGFIN, NMB
Protein Interaction Partner: SMAD4
Protein Size: 560 - Molecular Weight
- 60 kDa
- Gene ID
- 10457
- NCBI Accession
- NM_002510, NP_002501
- UniProt
- Q14956
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