Membrane Metallo-Endopeptidase (MME) (C-Term) Peptide

Details for Product No. ABIN980144, Supplier: Log in to see
Protein Name
  • CALLA
  • CD10
  • NEP
  • SFE
  • 6030454K05Rik
  • C85356
  • Nep
  • neprilysin
  • membrane metalloendopeptidase
  • membrane metallo endopeptidase
  • membrane metallo-endopeptidase
  • MME
  • Mme
Protein Region
C-Term
Origin
Human
7
7
7
1
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Blocked Antibody anti-MME antibody (Membrane Metallo-Endopeptidase) (C-Term) (ABIN2789467)
Sequence EYAVNSIKTD VHSPGNFRII GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW
Characteristics This is a synthetic peptide designed for use in combination with anti-MME Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.

Alias Symbols: CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP, SFE

Protein Interaction Partner: ADCYAP1,ADM,CSNK2B,EDN1,EDN2,GAST,LYN,NDRG1,NPPA,NPPC,PIK3CB,PIK3R1,SHC1,VIP,ALDH3A2,ARL1,ARMC10,ATP12A,ATP5J2,CD4,CDK5RAP3,CLEC4M,CPSF6,CSNK2A1,DNAJB12,EEF1A1,FAAH,FAHD1,FAM83F,FECH,FLOT2,FOLH1,HIST1H2AG,HSPA1A,HSPA4,HSPA8,HSPB1,IMPDH2,INPP5D,IRAK2,ITFG3,KBTBD3,KRT10,LAMTOR1,LMNA,LONP1,LYN,METTL7A,MME,MRPL44,MRPS25,MRVI1,MTDH,MTHFD1,MYH9,NDUFA10,NDUFA9,NDUFB4,NNT,NOLC1,NUCKS1,OPA1,PCNA,PDIA5,POTEI,RAP2B,RBM39,RGPD6,RPL30,RPS10,RPS23,RUVBL1,RUVBL2,SDF4,SLC16A1,SLC9A3R1,SRSF11,SSR4,TM9SF1,TNPO1,TUBB8,UBAC2,UTRN,VDAC2,XRCC5,ZMPSTE24

Protein Size: 750
Molecular Weight 83 kDa
Gene ID 4311
NCBI Accession NM_007287, NP_009218
UniProt P08473
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.