Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (N-Term) Peptide
NR3C1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all Glucocorticoid Receptor (NR3C1) products
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NR3C1 antibody (Catalog #: ARP45593_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
- Synonyms
- GR Peptide, gcr Peptide, grl Peptide, xGR Peptide, gccr Peptide, gr Peptide, zgc:113038 Peptide, NR3C1 Peptide, GCL Peptide, LOC100302444 Peptide, Gcr Peptide, Grl Peptide, Grl-1 Peptide, Grl1 Peptide, GRL Peptide, GCCR Peptide, GCR Peptide, NO Peptide, GR-A Peptide, nr3c1 Peptide, nuclear receptor subfamily 3 group C member 1 Peptide, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Peptide, nuclear receptor subfamily 3, group C, member 1 Peptide, glucocorticoid receptor Peptide, NR3C1 Peptide, nr3c1 Peptide, LOC100302444 Peptide, Nr3c1 Peptide
- Background
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NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Alias Symbols: GCCR, GCR, GR, GRL
Protein Interaction Partner: KDM5A,NCOA2,TP53,ADA,AR,BAG1,CALM1,CALR,CEBPA,CEBPB,CHD9,COPS6,CREB1,CREBBP,DAP3,DCAF6,DDX54,ECD,ETS1,ETS2,FKBP4,FYN,GRIP1,HNRNPU,HSP90AA1,HSPA1A,IDE,IFNGR2,JUN,KDM5A,KPNA2,LCK,MAPK1,MAPK15,MAPK8,MDM2,MED14,NCL,NCOA1,NCOA2,NCOA6,NCOR1,NCOR2,NFKB1,NFKB2,NR2F2,NR2F6,NR3C1,NR3C2,NRIP1,ONECUT1,PBX1,POU1F1,POU2F1,POU2F2,PPARGC1A,PRKACA,PRKDC,PSMC3IP,PTGES3,PTMS,RAF1,RELA,RNF14,SFN,SLC25A4,SMAD3,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCD1,SMARCE1,STAT3,STAT5A,STAT5B,SUMO1,SUMO4,SYT1,TBP,TGFB1I1,TP53,TRIM24,TRIM28,TSG101,TXN,UBB,UBE2I,YWHAH,ZBTB16,ADA,ARPC5,BAG1,CALR,CEBPA,CEBPB,CREB1,CREBBP,DAP3,DAXX,DDX54,ECD,ETS2,FKBP4,HMGB1,HMGB2,HNRNPU,HOXB1,HSP90AA1,HSPA1A,HSPD1,JUN,KDM5A,MED1,MED14,NCL,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NEDD4L,NFKB1,NFKB2,NR2F6,NR3C1,NR3C2,NRIP1,ONECUT1,PBX1,PIAS2,POU1F1,POU2F1,POU2F2,PPARGC1A,PSMC3IP,PTGES3,Psmc3ip,RAD9A,RAF1,RAN,RANBP9,RELA,SFN,SFPQ,SMAD3,SMARCA4,SMARCC1,SMARCD1,SMARCE1,STAT3,STAT5B,SVIL,TADA2A,TBP,TDG,TGFB1I1,TP53,TRIM24,TRIM28,TSG101,TXN,YWHAH,ZBTB16
Protein Size: 777 - Molecular Weight
- 86 kDa
- Gene ID
- 2908
- NCBI Accession
- NM_000176, NP_000167
- UniProt
- P04150
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