Protocadherin alpha 6 (PCDHA6) Peptide
PCDHA6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PCDHA6 products
- PCDHA6 (Protocadherin alpha 6 (PCDHA6))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PCDHA6 antibody (Catalog #: ARP50008_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PCDHA6 (Protocadherin alpha 6 (PCDHA6))
- Synonyms
- CNR2 Peptide, CNRN2 Peptide, CNRS2 Peptide, CRNR2 Peptide, PCDH-ALPHA6 Peptide, CNR Peptide, Cnr2 Peptide, Crnr2 Peptide, rCNRv06 Peptide, PCDHA3 Peptide, PCDHA6 Peptide, PCDHA7 Peptide, PCDHA9 Peptide, protocadherin alpha 6 Peptide, PCDHA6 Peptide, Pcdha6 Peptide
- Background
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PCDHA6 contains 6 cadherin domains. It is a potential calcium-dependent cell-adhesion protein. PCDHA6 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6
Protein Interaction Partner: RELN
Protein Size: 803 - Molecular Weight
- 84 kDa
- Gene ID
- 56142
- NCBI Accession
- NM_031848, NP_114036
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