Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) Peptide
PCSK1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all PCSK1 products
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PCSK1 antibody (Catalog #: ARP33848_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- Synonyms
- BMIQ12 Peptide, NEC1 Peptide, PC1 Peptide, PC3 Peptide, SPC3 Peptide, Nec-1 Peptide, Nec1 Peptide, Phpp-1 Peptide, BDP Peptide, PC1/3 Peptide, proprotein convertase subtilisin/kexin type 1 Peptide, prohormone convertase 1 Peptide, PCSK1 Peptide, Pcsk1 Peptide, pcsk1 Peptide, PC1B Peptide
- Background
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PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NEC1, PC1, PC3, SPC3, BMIQ12
Protein Interaction Partner: IAPP,PCSK1N,PMCH,REN,CTNNB1,PTK2
Protein Size: 753 - Molecular Weight
- 71 kDa
- Gene ID
- 5122
- NCBI Accession
- NM_000439, NP_000430
- UniProt
- P29120
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