Structural Maintenance of Chromosomes 1A (SMC1A) Peptide
SMC1A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SMC1A products
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SMC1A antibody (Catalog #: ARP38780_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
- Synonyms
- CDLS2 Peptide, DXS423E Peptide, SB1.8 Peptide, SMC1 Peptide, SMC1L1 Peptide, SMC1alpha Peptide, SMCB Peptide, SMC-1A Peptide, NV15570 Peptide, 5830426I24Rik Peptide, Sb1.8 Peptide, Smc1 Peptide, Smc1alpha Peptide, Smc1l1 Peptide, Smcb Peptide, mKIAA0178 Peptide, smc1 Peptide, smc1a Peptide, smc1l1 Peptide, xSMC1 Peptide, smc1aa Peptide, structural maintenance of chromosomes 1A Peptide, structural maintenance of chromosomes 1A b Peptide, structural maintenance of chromosomes 1A L homeolog Peptide, SMC1A Peptide, smc1a Peptide, Smc1a Peptide, smc1ab Peptide, smc1a.L Peptide
- Background
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The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by SMC1A gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the SMC1A protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Protein Interaction Partner: ATM,BLM,BRCA1,MCM6,MCM7,MDC1,MET,MSH2,NDC80,NUMA1,POLA1,RAD21,RFC1,RPGR,SMC3,AIRE,ATM,ATRX,CASP4,CDK4,CHTF18,MLH1,MSH6,NUMA1,RAD21,RAE1,REC8,SMARCA5,SMC1A,SMC3,STAG1,STAG3,STYXL1,SYCP3,USP13,USP32
Protein Size: 1233 - Molecular Weight
- 143 kDa
- Gene ID
- 8243
- NCBI Accession
- NM_006306, NP_006297
- UniProt
- Q14683
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