Suppressor of Cytokine Signaling 2 (SOCS2) (C-Term) Peptide
SOCS2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SOCS2 products
- SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KQFDSVVHLI DYYVQMCKDK RTGPEAPRNG TVHLYLTKPL YTSAPSLQHL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SOCS2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
- Synonyms
- CIS2 Peptide, Cish2 Peptide, SOCS-2 Peptide, SSI-2 Peptide, SSI2 Peptide, STATI2 Peptide, Cish1 Peptide, Socs-1 Peptide, Socs-2 Peptide, si:dkey-202b22.1 Peptide, socs2 Peptide, cis2 Peptide, ssi2 Peptide, cish2 Peptide, ssi-2 Peptide, socs-2 Peptide, stati2 Peptide, 8030460M17 Peptide, AI527257 Peptide, AW108012 Peptide, D130043N08Rik Peptide, JAB Peptide, hg Peptide, Cradd Peptide, Socs2 Peptide, suppressor of cytokine signaling 2 Peptide, suppressor of cytokine signaling 1 Peptide, death domain-containing protein CRADD Peptide, suppressor of cytokine signaling 2 S homeolog Peptide, SOCS2 Peptide, Socs1 Peptide, Socs2 Peptide, socs2 Peptide, LOC100716104 Peptide, socs2.S Peptide
- Background
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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
Alias Symbols: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Protein Interaction Partner: IGF1R,EPOR,GHR,IGF1R,INSR,PRLR,PTK2,SOCS3,EPOR,GHR,IGF1R,PRLR,PTK2,SOCS1
Protein Size: 198 - Molecular Weight
- 22 kDa
- Gene ID
- 8835
- NCBI Accession
- NM_003877, NP_003868
- UniProt
- O14508
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