UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) (N-Term) Peptide
UGT1A1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all UGT1A1 products
- UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-UGT1A1 antibody (Catalog #: ARP44292_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
- Synonyms
- BILIQTL1 Peptide, GNT1 Peptide, HUG-BR1 Peptide, UDPGT Peptide, UDPGT 1-1 Peptide, UGT1 Peptide, UGT1A Peptide, Gnt1 Peptide, UGT1A01 Peptide, Udpgt-1a Peptide, UgtBr1 Peptide, Udpgt Peptide, Ugt1 Peptide, zgc:123097 Peptide, UDP glucuronosyltransferase family 1 member A1 Peptide, UDP glucuronosyltransferase 1 family, polypeptide A1 Peptide, UDP-glucuronosyltransferase 1-1 Peptide, UDP-glucuronosyltransferase Peptide, UDP-glucuronosyltransferase 1-6 Peptide, UDP glucuronosyltransferase 1 family polypeptide a1 Peptide, UGT1A1 Peptide, Ugt1a1 Peptide, LOC100065342 Peptide, LOC100125517 Peptide, LOC100229734 Peptide, LOC100405984 Peptide, LOC100511479 Peptide, ugt1a1 Peptide
- Background
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UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GNT1, HUG-BR1, UDPGT, UGT1, UGT1A, BILIQTL1, UDPGT 1-1
Protein Interaction Partner: B3GALT1
Protein Size: 533 - Molecular Weight
- 57 kDa
- Gene ID
- 54658
- NCBI Accession
- NM_000463, NP_000454
- UniProt
- P22309
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